{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:17:21Z","timestamp":1790691441639,"version":"4.1.0"},"reference-count":33,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"name":"local research committee at NSR hospital","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"the regional research committee of Region Zealand","award":["13-000849"],"award-info":[{"award-number":["13-000849"]}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["16-R107-A6819-22020"],"award-info":[{"award-number":["16-R107-A6819-22020"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To examine differences in myocardial blood flow (MBF) at rest and during stress between patients with type 2 diabetes and control subjects, and to identify potential predictors of changes in MBF at rest and during stress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A cross-sectional study was conducted of 193 patients with type 2 diabetes and 20 age- and sex-matched control subjects. Cardiovascular magnetic resonance was used to evaluate left ventricular structure and function and MBF at rest and during adenosine-induced stress. MBF was derived as the mean of the flow within all segments of a midventricular slice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Patients with type 2 diabetes had higher global MBF at rest (0.81 \u00b1 0.19 mL\/min\/g) and lower global MBF during stress (2.4 \u00b1 0.9 mL\/min\/g) than control subjects (0.61 \u00b1 0.11 at rest, 3.2 \u00b1 0.8 mL\/min\/g under stress; both P &amp;lt; 0.01). Patients with macroalbuminuria had lower MBF during stress (1.6 \u00b1 0.5 mL\/min\/g) than did patients with microalbuminuria (2.1 \u00b1 0.7 mL\/min\/g; P = 0.04), who in turn had lower MBF during stress than did normoalbuminuric patients (2.7 \u00b1 0.9 mL\/min\/g; P &amp;lt; 0.01). Patients with severe retinopathy had lower MBF during stress (1.8 \u00b1 0.6 mL\/min\/g) than patients with simplex retinopathy (2.3 \u00b1 0.7 mL\/min\/g; P &amp;lt; 0.05) and those who did not have retinopathy (2.6 \u00b1 1.0 mL\/min\/g; P &amp;lt; 0.05). Albuminuria and retinopathy were associated with reduced MBF during stress in a multiple regression analysis. Stress-related MBF inversely correlated with myocardial extracellular volume (P &amp;lt; 0.001; R2 = 0.37), a measure of diffuse myocardial fibrosis. A trend toward lower basal MBF was observed in patients treated with sodium\u2013glucose cotransporter 2 inhibitors (P = 0.07).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patients with type 2 diabetes have higher global MBF at rest and lower maximal MBF during vasodilator-induced stress than control subjects. Reduced MBF during stress is associated with diabetes complications (albuminuria and retinopathy) and is inversely correlated with diffuse myocardial fibrosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc19-2172","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T03:30:33Z","timestamp":1584675033000},"page":"1285-1292","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":45,"title":["Reduced Myocardial Perfusion Reserve in Type 2 Diabetes Is Caused by Increased Perfusion at Rest and Decreased Maximal Perfusion During Stress"],"prefix":"10.2337","volume":"43","clinical-trial-number":[{"clinical-trial-number":"nct02684331","registry":"10.18810\/clinical-trials-gov","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-6203","authenticated-orcid":false,"given":"Martin H.","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Cardiology and Endocrinology, Slagelse Hospital, Region Zealand, Denmark"},{"name":"Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemie S.","family":"Bojer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Endocrinology, Slagelse Hospital, Region Zealand, Denmark"},{"name":"Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.N.","family":"Pontoppidan","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Endocrinology, Slagelse Hospital, Region Zealand, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Broadbent","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Engineering, Leeds Teaching Hospitals NHS Trust, Leeds, U.K."},{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Plein","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per L.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Capital Region of Denmark, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"G\u00e6de","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Endocrinology, Slagelse Hospital, Region Zealand, Denmark"},{"name":"Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"2022031300322619100_B1","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.2337\/dc12-1513","article-title":"All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large U.K. primary care database","volume":"36","author":"Taylor","year":"2013","journal-title":"Diabetes Care"},{"key":"2022031300322619100_B2","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.282.12.1132","article-title":"Diabetes and decline in heart disease mortality","volume":"282","author":"Poothullil","year":"1999","journal-title":"JAMA"},{"key":"2022031300322619100_B3","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.2105\/AJPH.81.9.1158","article-title":"Cause-specific mortality in a population-based study of diabetes","volume":"81","author":"Moss","year":"1991","journal-title":"Am J Public Health"},{"key":"2022031300322619100_B4","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0735-1097(00)00582-9","article-title":"Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study","volume":"35","author":"Gottdiener","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2022031300322619100_B5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am J Cardiol"},{"key":"2022031300322619100_B6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/path.1711660308","article-title":"Human coronary microvessels in diabetes and ischaemia. 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