{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:12:20Z","timestamp":1784131940970,"version":"3.55.0"},"reference-count":40,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>The aim of this study was to examine the association of circulating retinol-binding protein 4 (RBP4) levels with \u03b2-cell function across the spectrum of glucose tolerance from normal to overt type 2 diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A total of 291 subjects aged 35\u201360 years with normal glucose tolerance (NGT), newly diagnosed impaired fasting glucose or glucose tolerance (IFG\/IGT), or type 2 diabetes were screened by a standard 2-h oral glucose tolerance test (OGTT) with the use of traditional measures to evaluate \u03b2-cell function. From these participants, 74 subjects were recruited for an oral minimal model test, and \u03b2-cell function was assessed with model-derived indices. Circulating RBP4 levels were measured by a commercially available ELISA kit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Circulating RBP4 levels were significantly and inversely correlated with \u03b2-cell function indicated by the Stumvoll first-phase and second-phase insulin secretion indices, but not with HOMA of \u03b2-cell function, calculated from the 2-h OGTT in 291 subjects across the spectrum of glycemia. The inverse association was also observed in subjects involved in the oral minimal model test with \u03b2-cell function assessed by both direct measures and model-derived measures, after adjustment for potential confounders. Moreover, RBP4 emerged as an independent factor of the disposition index-total insulin secretion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Circulating RBP4 levels are inversely and independently correlated with \u03b2-cell function across the spectrum of glycemia, providing another possible explanation of the linkage between RBP4 and the pathogenesis of type 2 diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc19-2432","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T21:51:05Z","timestamp":1586296265000},"page":"1258-1265","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["Circulating Retinol-Binding Protein 4 Is Inversely Associated With Pancreatic \u03b2-Cell Function Across the Spectrum of Glycemia"],"prefix":"10.2337","volume":"43","author":[{"given":"Rong","family":"Huang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong, People\u2019s Republic of China"},{"name":"Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping","family":"Yin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong, People\u2019s Republic of China"},{"name":"Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Ye","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong, People\u2019s Republic of China"},{"name":"Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong, People\u2019s Republic of China"},{"name":"Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong, People\u2019s Republic of China"},{"name":"Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People\u2019s Republic of 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