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Cohort II was a confirmatory cohort of 13 patients (BMI 39.3 \u00b1 1.4 kg\/m2) undergoing gastric bypass surgery. Cohort III comprised 15 healthy subjects (BMI 26.4 \u00b1 0.5 kg\/m2). Cohorts I and II completed a 2-h mixed-meal tolerance test (MTT) before the intervention and at 1 year of follow-up, and cohort II also completed a 3-h lipid test (LT). Cohort III underwent a 3-h oral glucose tolerance test (OGTT) and an isoglycemic intravenous glucose infusion (IIGI) study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In cohort I, succinate response to MTT at follow-up was greater than before the intervention (P &amp;lt; 0.0001). This response was confirmed in cohort II with a greater increase after 1 year of surgery (P = 0.009). By contrast, LT did not elicit a succinate response. Changes in succinate response were associated with changes in the area under the curve of glucose (r = 0.417, P &amp;lt; 0.0001) and insulin (r = 0.204, P = 0.002). In cohort III, glycemia, per se, stimulated a plasma succinate response (P = 0.0004), but its response was greater in the OGTT (P = 0.02; OGTT versus IIGI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The meal-related response of circulating succinate in patients with obesity and type 2 diabetes is recovered after metabolic surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc20-0460","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T23:29:38Z","timestamp":1596238178000},"page":"2581-2587","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":38,"title":["Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery"],"prefix":"10.2337","volume":"43","author":[{"given":"Brenno","family":"Astiarraga","sequence":"first","affiliation":[{"name":"Rovira I Virgili University (URV), Tarragona, Spain"},{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Tarragona Joan XXIII, Institut d\u02caInvestigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Tarragona Joan XXIII, Institut d\u02caInvestigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ceperuelo-Mallafr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Tarragona Joan XXIII, Institut d\u02caInvestigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Tarragona, Spain"},{"name":"CIBERDEM\u2013Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Llaurad\u00f3","sequence":"additional","affiliation":[{"name":"CIBERDEM\u2013Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Department of Endocrinology and Nutrition, Hospital del Mar, Institut Hospital del Mar d'Investigacions M\u00e8diques, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Terr\u00f3n-Puig","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Tarragona Joan XXIII, Institut d\u02caInvestigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Tarragona, Spain"},{"name":"CIBERDEM\u2013Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mar","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitari de Tarragona Joan XXIII, Institut d\u02caInvestigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Tarragona, Spain"},{"name":"CIBERDEM\u2013Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Casajoana","sequence":"additional","affiliation":[{"name":"General Surgery Department, Hospital Universitari de Bellvitge, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pellitero","sequence":"additional","affiliation":[{"name":"CIBERDEM\u2013Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Department of Endocrinology and Nutrition, Germans Trias I Pujol Research Institute, Barcelona, 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