{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:11:27Z","timestamp":1788534687162,"version":"build-2803163510"},"reference-count":29,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with new-onset coronary artery disease (CAD) or cerebrovascular disease (CVD) according to glucose status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Examined was a nationwide claims database from 2008 to 2016 on 593,196 individuals. A Cox proportional hazards model identified risks of CAD and CVD events among five levels of SBP and DBP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>During the study period 2,240 CAD and 3,207 CVD events occurred. Compared with SBP \u2264119 mmHg, which was the lowest quintile of SBP, hazard ratios (95% CI) for CAD\/CVD in the 4 higher quintiles (120\u2013129, 130\u2013139, 140\u2013149, \u2265150 mmHg) gradually increased from 2.10 (1.73\u20132.56)\/1.46 (1.27\u20131.68) in quintile 2 to 3.21 (2.37\u20134.34)\/4.76 (3.94\u20135.75) in quintile 5 for normoglycemia, from 1.39 (1.14\u20131.69)\/1.70 (1.44\u20132.01) in quintile 2 to 2.52 (1.95\u20133.26)\/4.12 (3.38\u20135.02) in quintile 5 for borderline glycemia, and from 1.50 (1.19\u20131.90)\/1.72 (1.31\u20132.26) in quintile 2 to 2.52 (1.95\u20133.26)\/3.54 (2.66\u20134.70) in quintile 5 for diabetes. A similar trend was observed for DBP across 4 quintiles (75\u201379, 80\u201384, 85\u201389, and \u226590 mmHg) compared with \u226574 mmHg, which was the lowest quintile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Results indicated that cardiovascular risks gradually increased with increases in SBP and DBP regardless of the presence of and degree of a glucose abnormality. Further interventional trials are required to apply findings from this cohort study to clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc20-2252","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T21:25:28Z","timestamp":1621977928000},"page":"2124-2131","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":42,"title":["Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status"],"prefix":"10.2337","volume":"44","author":[{"given":"Mayuko Harada","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan"},{"name":"Division of Diabetes and Endocrinology and Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, 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