{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:19:33Z","timestamp":1780460373237,"version":"3.54.1"},"reference-count":30,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Bone biopsy (BB) performed by a surgeon or an interventional radiologist is recommended for suspicion of osteomyelitis underlying diabetic foot ulcer (DFU). To facilitate its practice, we developed a procedure allowing bedside blind bone biopsy (B4) by a diabetologist.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We conducted a three-step observational study consisting of a feasibility and safety phase (phase 1) to assess the success and side effects of B4, a validity phase (phase 2) to compare DFU outcomes between positive (B4+) and negative (B4\u2212) bone cultures, and a performance phase (phase 3) to compare B4 with the conventional surgical or radiological procedure basic bone biopsy (B3). Primary end points were the presence of bone tissue (phase 1) and complete DFU healing with exclusive medical treatment at 12 months (phases 2 and 3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In phase 1, 37 consecutive patients with clinical and\/or radiological suspicion of DFU osteomyelitis underwent B4. Bone tissue was collected in all patients with few side effects. In phase 2, a B4+ bone culture was found in 40 of 79 (50.6%) participants. Among B4+ patients, complete wound healing after treatment was 57.5%. No statistical difference was observed with patients with B4\u2212 bone culture not treated with antibiotics (71.8%, P = 0.18). In phase 3, the proportion of patients with positive BB was lower in B4 (40 of 79, 50.6%) than in B3 (34 of 44, 77.3%, P &amp;lt; 0.01). However, complete healing was similar (64.6% vs. 54.6%, P = 0.28). No difference in rate of culture contamination was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>B4 is a simple, safe, and efficient procedure for the diagnosis of DFU osteomyelitis with a similar proportion of healing to conventional BB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc20-3170","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:50:12Z","timestamp":1630612212000},"page":"2480-2486","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":21,"title":["Reliability and Safety of Bedside Blind Bone Biopsy Performed by a Diabetologist for the Diagnosis and Treatment of Diabetic Foot Osteomyelitis"],"prefix":"10.2337","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7151-8964","authenticated-orcid":false,"given":"Florine","family":"F\u00e9ron","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier P\u00e9an","family":"de Ponfilly","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Potier","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Nutrition, Bichat Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"},{"name":"Cordeliers Research Centre, INSERM, Immunity and Metabolism in Diabetes Laboratory, Sorbonne University, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane-C\u00e9cile","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Salle","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Laloi-Michelin","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"Munier","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Jacquier","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphaine","family":"Vidal-Tr\u00e9can","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Julla","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"},{"name":"Cordeliers Research Centre, INSERM, Immunity and Metabolism in Diabetes Laboratory, Sorbonne University, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Carlier","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Nutrition, Bichat Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawa","family":"Abouleka","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Nutrition, Bichat Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Venteclef","sequence":"additional","affiliation":[{"name":"Cordeliers Research Centre, INSERM, Immunity and Metabolism in Diabetes Laboratory, Sorbonne University, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Grall","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Bichat Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Mercier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Parc Monceau International Clinic, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-0741","authenticated-orcid":false,"given":"Jean-Pierre","family":"Riveline","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"},{"name":"Cordeliers Research Centre, INSERM, Immunity and Metabolism in Diabetes Laboratory, Sorbonne University, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5720-8908","authenticated-orcid":false,"given":"\u00c9ric","family":"Senneville","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Gustave Dron Hospital, Tourcoing, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-2001","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Gautier","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Lariboisi\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"},{"name":"Cordeliers Research Centre, INSERM, Immunity and Metabolism in Diabetes Laboratory, Sorbonne University, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Roussel","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Nutrition, Bichat Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"},{"name":"Cordeliers Research Centre, INSERM, Immunity and Metabolism in Diabetes Laboratory, Sorbonne University, Universit\u00e9 de Paris, Paris, 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