{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:10:11Z","timestamp":1773288611270,"version":"3.50.1"},"reference-count":8,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration &amp;lt;3.3 mmol\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol\/L in the BHBP period versus 9 (1.8) mmol\/L in the UC period (P = 0.13). Mean (SD) time with CGM glucose concentration &amp;lt;3.3 mmol\/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period (P = 0.11).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Relative to UC, the BHBP resulted in comparable glycemic control in our population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc21-0416","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T16:15:14Z","timestamp":1631549714000},"page":"2582-2585","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":9,"title":["The Bihormonal Bionic Pancreas Improves Glycemic Control in Individuals With Hyperinsulinism and Postpancreatectomy Diabetes: A Pilot Study"],"prefix":"10.2337","volume":"44","clinical-trial-number":[{"clinical-trial-number":"nct03303196","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Arpana","family":"Rayannavar","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Mitteer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney A.","family":"Balliro","sequence":"additional","affiliation":[{"name":"Diabetes Research Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas H.","family":"El-Khatib","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"Lord","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA"},{"name":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin P.","family":"Hawkes","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA"},{"name":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance S.","family":"Ballester","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Management Core, The Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Damiano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-5891","authenticated-orcid":false,"given":"Steven J.","family":"Russell","sequence":"additional","affiliation":[{"name":"Diabetes Research Center and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-8087","authenticated-orcid":false,"given":"Diva D.","family":"De Le\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, The 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