{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:44:12Z","timestamp":1788986652461,"version":"build-2803163510"},"reference-count":38,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,7]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Gestational hyperglycemia is associated with deleterious neonatal outcomes, but long-term risks for offspring obesity are less clear. We estimated the odds for offspring adolescent overweight and obesity among mothers with gestational glucose intolerance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>In a mother-offspring historical cohort, the Israel military conscription data set was linked to a large health maintenance organization. Included were women who were evaluated at adolescence and underwent two-step gestational diabetes screening (mean age, 31 years) with a 50-g glucose challenge test (GCT), followed by a 100-g oral glucose tolerance test (OGTT) if the result was abnormal. Glucose tolerance categories included gestational normoglycemia, abnormal GCT with normal OGTT, impaired glucose tolerance (IGT; one abnormal OGTT value), and gestational diabetes. The primary outcome was offspring overweight\/obesity (BMI \u226585th percentile) at adolescence, measured prior to military conscription. Logistic regression models were applied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of 33,482 mother-offspring pairs, overweight and obesity were observed in 6,516 offspring. Across increasing categories of pregnancy glycemia, the proportions of offspring with adolescent overweight\/obesity increased: normoglycemia, 19%; abnormal GCT with normal OGTT, 22%; gestational IGT, 24%; and gestational diabetes, 25% (P &amp;lt; 0.0001). Corresponding odds ratios after adjustment for the mother\u2019s late adolescent characteristics (sociodemographic confounders and BMI) and pregnancy age were 1.2 (95% CI 1.1\u20131.4), 1.3 (1.2\u20131.5), and 1.4 (1.3\u20131.6), respectively. Further adjustment for offspring birth weight percentile and sociodemographic variables did not materially change results. Associations were more pronounced with increasing obesity severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Gestational glucose intolerance, including categories not meeting the gestational diabetes threshold, was associated with increased odds for offspring overweight\/obesity at late adolescence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc21-2634","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T14:51:24Z","timestamp":1654613484000},"page":"1540-1548","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":42,"title":["Glucose Intolerance in Pregnancy and Offspring Obesity in Late Adolescence"],"prefix":"10.2337","volume":"45","author":[{"given":"Cole D.","family":"Bendor","sequence":"first","affiliation":[{"name":"1Department of Military Medicine, Hebrew University, Jerusalem, and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Bardugo","sequence":"additional","affiliation":[{"name":"1Department of Military Medicine, Hebrew University, Jerusalem, and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran Shmuel","family":"Rotem","sequence":"additional","affiliation":[{"name":"2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"3Kahn-Sagol-Maccabi Research and Innovation Institute, Maccabi Healthcare Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Derazne","sequence":"additional","affiliation":[{"name":"1Department of Military Medicine, Hebrew University, Jerusalem, and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"},{"name":"4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hertzel C.","family":"Gerstein","sequence":"additional","affiliation":[{"name":"5Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorit","family":"Tzur","sequence":"additional","affiliation":[{"name":"1Department of Military Medicine, Hebrew University, Jerusalem, and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Pinhas-Hamiel","sequence":"additional","affiliation":[{"name":"4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"6Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children\u2019s Hospital, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avishai M.","family":"Tsur","sequence":"additional","affiliation":[{"name":"1Department of Military Medicine, Hebrew University, Jerusalem, and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"},{"name":"4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"7Department of Medicine \u201cB,\u201d Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Cukierman-Yaffe","sequence":"additional","affiliation":[{"name":"4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"8Institute of Endocrinology, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Lebenthal","sequence":"additional","affiliation":[{"name":"4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"9Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Afek","sequence":"additional","affiliation":[{"name":"4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"10Central Management, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[{"name":"4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"11Maccabitech, Maccabi Healthcare Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2829-3645","authenticated-orcid":false,"given":"Gilad","family":"Twig","sequence":"additional","affiliation":[{"name":"1Department of Military Medicine, Hebrew University, Jerusalem, and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"},{"name":"8Institute of Endocrinology, Sheba Medical Center, Ramat Gan, Israel"},{"name":"12Department of Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2022,6,4]]},"reference":[{"key":"2022070714525227500_B1","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG Practice Bulletin No. 190: gestational diabetes mellitus","volume":"131","author":"American College of Obstetricians and Gynecologists Committee on Practice Bulletins\u2014Obstetrics","year":"2018","journal-title":"Obstet Gynecol"},{"key":"2022070714525227500_B2","unstructured":"International Diabetes Federation\n          . 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