{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:56:37Z","timestamp":1790283397435,"version":"4.1.0"},"reference-count":31,"publisher":"American Diabetes Association","issue":"11","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","award":["ERP-2019-12000"],"award-info":[{"award-number":["ERP-2019-12000"]}],"id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the outcomes of transitioning to the MiniMed 780G advanced hybrid closed-loop (AHCL) system in adult individuals with type 1 diabetes mellitus (T1DM) naive to continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) technologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>This was a two-center, randomized, controlled, parallel-group trial with evaluation of individuals with T1DM aged 26\u201360 years managed with multiple daily injections (MDI) and self-monitoring of blood glucose (BGM) with HbA1c &amp;lt;10%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 41 participants were recruited and randomized to either the AHCL (n = 20) or the MDI+BGM (n = 21) group, and 37 participants (mean \u00b1 SD age 40.3 \u00b1 8.0 years, duration of diabetes 17.3 \u00b1 12.1 years, BMI 25.1 \u00b1 3.1 kg\/m2, HbA1c 7.2 \u00b1 1.0%) completed the study. Time spent with glucose levels in target range increased from 69.3 \u00b1 12.3% at baseline to 85.0 \u00b1 6.3% at 3 months in the AHCL group, while remaining unchanged in the control group (treatment effect 21.5% [95% CI 15.7, 27.3]; P &amp;lt; 0.001). The time with levels below range (&amp;lt;70 mg\/dL) decreased from 8.7 \u00b1 7.3% to 2.1 \u00b1 1.7% in the AHCL group and remained unchanged in the MDI+BGM group (treatment effect \u22124.4% [95% CI \u22127.4, \u22122.1]; P &amp;lt; 0.001). Participants from the AHCL group also had significant improvements in HbA1c levels (treatment effect \u22120.6% [95% CI \u22120.9, \u22120.2]; P = 0.005) and in quality of life (QoL) in specific subscales compared with the MDI+BGM group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>People with T1DM naive to CSII and CGM technologies initiating AHCL significantly and safely improved their glycemic control, as well as their QoL and psychological well-being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc22-0470","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T08:53:28Z","timestamp":1660640008000},"page":"2628-2635","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":66,"title":["Transitioning of People With Type 1 Diabetes From Multiple Daily Injections and Self-Monitoring of Blood Glucose Directly to MiniMed 780G Advanced Hybrid Closed-Loop System: A Two-Center, Randomized, Controlled Study"],"prefix":"10.2337","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-352X","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"Matejko","sequence":"first","affiliation":[{"name":"1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland"},{"name":"2University Hospital in Krakow, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Juza","sequence":"additional","affiliation":[{"name":"3Clinical Provincial Hospital of Frederic Chopin No. 1 in Rzesz\u00f3w, Rzesz\u00f3w, Poland"},{"name":"4College of Medical Sciences, University of Rzesz\u00f3w, Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kie\u0107-Wilk","sequence":"additional","affiliation":[{"name":"1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland"},{"name":"2University Hospital in Krakow, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Cyranka","sequence":"additional","affiliation":[{"name":"1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland"},{"name":"2University Hospital in Krakow, Krakow, Poland"},{"name":"5Department of Psychiatry, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Krzy\u017cowska","sequence":"additional","affiliation":[{"name":"2University Hospital in Krakow, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Chen","sequence":"additional","affiliation":[{"name":"6Medtronic, Northridge, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohad","family":"Cohen","sequence":"additional","affiliation":[{"name":"7Medtronic International Trading S\u00e0rl, Tolochenaz, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Da Silva","sequence":"additional","affiliation":[{"name":"7Medtronic International Trading S\u00e0rl, Tolochenaz, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej T.","family":"Malecki","sequence":"additional","affiliation":[{"name":"1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland"},{"name":"2University Hospital in Krakow, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-4079","authenticated-orcid":false,"given":"Tomasz","family":"Klupa","sequence":"additional","affiliation":[{"name":"1Department of Metabolic Diseases, Jagiellonian University Medical College, 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