{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:24:39Z","timestamp":1794410679153,"version":"4.9.0"},"reference-count":26,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142dowska-Curie Actions","doi-asserted-by":"publisher","award":["860898"],"award-info":[{"award-number":["860898"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To investigate trends in incidence rates (IRs) at various fracture sites for patients with type 1 diabetes and type 2 diabetes compared with patients without diabetes in Denmark in 1997\u20132017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>Patients aged \u226518 years with a vertebral, hip, humerus, forearm, foot, or ankle fracture between 1997 and 2017 were identified from Danish hospital discharge data. IRs per 10,000 person-years were calculated over the study period. Median IRs for the first (1997\u20132001) and the last (2013\u20132017) 5 years were compared. We used Poisson models to estimate age-adjusted IR ratios (IRRs) of fractures among patients with type 1 and type 2 diabetes versus patients without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Except for foot fractures, fracture IRs were higher in patients with type 1 or type 2 diabetes compared with patients without diabetes. Hip fracture IRs declined between the first and last 5 years by 35.2%, 47.0%, and 23.4% among patients with type 1, type 2, and without diabetes, respectively. By contrast, vertebral fracture IRs increased 14.8%, 18.5%, 38.9%, respectively. While age-adjusted IRRs remained elevated in patients with type 1 diabetes compared with patients without diabetes, IRRs in patients with type 2 diabetes converged with those observed in patients without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Unadjusted fracture rates are higher in patients with diabetes but have decreased between 1997 and 2017 except for vertebral fractures, which increased in all groups. Fracture rates change after age adjustment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc22-1004","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T13:35:35Z","timestamp":1674653735000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":27,"title":["Site-Specific Fracture Incidence Rates Among Patients With Type 1 Diabetes, Type 2 Diabetes, or Without Diabetes in Denmark (1997\u20132017)"],"prefix":"10.2337","volume":"46","author":[{"given":"Annika Vestergaard","family":"Kvist","sequence":"first","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Molecular Endocrinology Stem Cell Research Unit (KMEB), Odense University Hospital, Odense, Denmark"},{"name":"2Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"3Pharmacoepidemiology Group, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Insititue of Technology (ETH) Zurich, Zurich, Switzerland"},{"name":"4Steno Diabetes Center North Denmark, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad I.","family":"Nasser","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Molecular Endocrinology Stem Cell Research Unit (KMEB), Odense University Hospital, Odense, Denmark"},{"name":"2Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"5Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"4Steno Diabetes Center North Denmark, Aalborg, Denmark"},{"name":"6Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"7Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Frost","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Molecular Endocrinology Stem Cell Research Unit (KMEB), Odense University Hospital, Odense, Denmark"},{"name":"2Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"5Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-8530","authenticated-orcid":false,"given":"Andrea M.","family":"Burden","sequence":"additional","affiliation":[{"name":"3Pharmacoepidemiology Group, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Insititue of Technology (ETH) Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"2023022220012211500_","doi-asserted-by":"crossref","first-page":"P134","DOI":"10.1016\/S0140-6736(55)92135-8","volume":"266","author":"International Diabetes Federation","year":"1955","journal-title":"Lancet"},{"key":"2023022220012211500_","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/bmjdrc-2019-001064","article-title":"Components of diabetes prevalence in Denmark 1996-2016 and future trends until 2030","volume":"8","author":"Carstensen","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2023022220012211500_","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/aje\/kwm106","article-title":"Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture","volume":"166","author":"Janghorbani","year":"2007","journal-title":"Am J 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Diabetes demography, cardiometabolic risk factors, and acute- and chronic diabetes complications in a nationwide diabetes registry in Denmark. 2020. Accessed 1 January 2023. 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