{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:39:25Z","timestamp":1792024765671,"version":"4.4.0"},"reference-count":37,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To analyze the impact of modern glucose-monitoring strategies on glycemic and patient-related outcomes in individuals with type 2 diabetes (T2D) and recent myocardial infarction (MI) and assess cost effectiveness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>LIBERATES was a multicenter two-arm randomized trial comparing self-monitoring of blood glucose (SMBG) with intermittently scanned continuous glucose monitoring (isCGM), also known as flash CGM, in individuals with T2D and recent MI, treated with insulin and\/or a sulphonylurea before hospital admission. The primary outcome measure was time in range (TIR) (glucose 3.9\u201310 mmol\/L\/day) on days 76\u201390 post-randomization. Secondary and exploratory outcomes included time in hypoglycemia, hemoglobin A1c (HbA1c), clinical outcome, quality of life (QOL), and cost effectiveness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of 141 participants randomly assigned (median age 63 years; interquartile range 53, 70), 73% of whom were men, isCGM was associated with increased TIR by 17 min\/day (95% credible interval \u2212105 to +153 min\/day), with 59% probability of benefit. Users of isCGM showed lower hypoglycemic exposure (&amp;lt;3.9 mmol\/L) at days 76\u201390 (\u221280 min\/day; 95% CI \u2212118, \u221243), also evident at days 16\u201330 (\u221228 min\/day; 95% CI \u221292, 2). Compared with baseline, HbA1c showed similar reductions of 7 mmol\/mol at 3 months in both study arms. Combined glycemic emergencies and mortality occurred in four isCGM and seven SMBG study participants. QOL measures marginally favored isCGM, and the intervention proved to be cost effective.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Compared with SMBG, isCGM in T2D individuals with MI marginally increases TIR and significantly reduces hypoglycemic exposure while equally improving HbA1c, explaining its cost effectiveness. Studies are required to understand whether these glycemic differences translate into longer-term clinical benefit.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc22-1219","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T17:46:02Z","timestamp":1671039962000},"page":"441-449","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":42,"title":["Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial"],"prefix":"10.2337","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-3725","authenticated-orcid":false,"given":"Ramzi A.","family":"Ajjan","sequence":"first","affiliation":[{"name":"1Clinical Population and Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-9565","authenticated-orcid":false,"given":"Simon R.","family":"Heller","sequence":"additional","affiliation":[{"name":"2Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin C.","family":"Everett","sequence":"additional","affiliation":[{"name":"3Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Vargas-Palacios","sequence":"additional","affiliation":[{"name":"4Academic Unit of Health Economics, University of Leeds, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Higham","sequence":"additional","affiliation":[{"name":"2Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Sharples","sequence":"additional","affiliation":[{"name":"5Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana A.","family":"Gorog","sequence":"additional","affiliation":[{"name":"6School of Life and Medical Science, University of Hertfordshire, Hertfordshire, U.K."},{"name":"7National Heart and Lung Institute, Imperial College London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Rogers","sequence":"additional","affiliation":[{"name":"8Patient representative"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Reynolds","sequence":"additional","affiliation":[{"name":"1Clinical Population and Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fernandez","sequence":"additional","affiliation":[{"name":"2Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"4Academic Unit of Health Economics, University of Leeds, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thozhukat","family":"Sathyapalan","sequence":"additional","affiliation":[{"name":"9Academic Diabetes, Endocrinology and Metabolism, Allam Diabetes Centre, Hull York Medical School, University of Hull, Hull, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Storey","sequence":"additional","affiliation":[{"name":"10Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, 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