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We sought to determine whether 1) AS is associated with cardiac target organ damage in young adults with youth-onset diabetes, 2) whether CAN is associated with AS, as one possible etiology for increased AS in this cohort, and 3) whether these relationships differ by type of diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESEARCH DESIGN AND METHODS<\/jats:title><jats:p>Participants from the SEARCH for Diabetes in Youth Study (type 1 diabetes [T1D], n = 222; type 2 diabetes [T2D], n = 177; mean age 23 years) had clinical, echocardiographic, AS, and CAN assessed. Linear regression was performed to determine whether AS was associated with cardiac changes and CAN and whether relationships differed by diabetes type.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>AS was significantly associated with cardiac structure (left ventricular mass index, P &amp;lt; 0.0001), systolic function (ejection fraction, P = 0.03) and diastolic function (transmitral peak early [E]\/atrial [A] wave velocities ratio, P = 0.008; early [e\u2032]\/atrial [a\u2032] waves, P = 0.02) after adjustments for CV risk factors. The association between AS and CAN was not significant when other important covariates were added. These relationships were mostly similar in both T1D and T2D.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>AS is associated with cardiac changes in young adults with diabetes. CAN-induced AS does not appear to be an etiology for cardiac abnormalities in this cohort.<\/jats:p><\/jats:sec>","DOI":"10.2337\/dc22-1703","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T19:52:52Z","timestamp":1675367572000},"page":"786-793","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":10,"title":["Association of Elevated Arterial Stiffness With Cardiac Target Organ Damage and Cardiac Autonomic Neuropathy in Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study"],"prefix":"10.2337","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5640-6777","authenticated-orcid":false,"given":"Elaine M.","family":"Urbina","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Isom","sequence":"additional","affiliation":[{"name":"2Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Dabelea","sequence":"additional","affiliation":[{"name":"3Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus (CU-Anschutz), Aurora, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Ralph","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"2Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Daniels","sequence":"additional","affiliation":[{"name":"4Department of Pediatrics, University of Colorado Anschutz Medical Campus (CU-Anschutz), Aurora, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence M.","family":"Dolan","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Imperatore","sequence":"additional","affiliation":[{"name":"5Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Lustigova","sequence":"additional","affiliation":[{"name":"6Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santica","family":"Marcovina","sequence":"additional","affiliation":[{"name":"7Department of Medicine, University of Washington, Seattle, 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