{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:49:22Z","timestamp":1788544162016,"version":"build-2803163510"},"reference-count":41,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"University Grants Committee Research Grants Matching Scheme"},{"name":"The Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Fund"},{"name":"The Postdoctoral Fellowship Scheme of the Chinese University of Hong Kong"},{"name":"Australia Joint Research Scheme","award":["81561128017"],"award-info":[{"award-number":["81561128017"]}]},{"name":"Research Grants Council Senior Research Fellow","award":["SRFS2021-4S04"],"award-info":[{"award-number":["SRFS2021-4S04"]}]},{"name":"The Focused Innovation Scheme, Vice-Chancellor One-off Discretionary Fund"},{"name":"Natural Science Foundation of China\u2013National Health and Medical Science Council"},{"name":"The Hong Kong Foundation for Research and Development in Diabetes, the Chinese University of Hong Kong"},{"name":"The Research Grants Council of the Hong Kong Special Administrative Region","award":["CU R4012-18"],"award-info":[{"award-number":["CU R4012-18"]}]},{"name":"The Croucher Foundation Senior Medical Research Fellowship"},{"name":"The Research Grants Council Theme-based Research Scheme","award":["T12-402\/13N"],"award-info":[{"award-number":["T12-402\/13N"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>In this study we aim to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>We performed a two-stage genome-wide association study for CHD in Chinese patients with T2D (3,596 case and 8,898 control subjects), followed by replications in European patients with T2D (764 case and 4,276 control subjects) and general populations (n = 51,442\u2013547,261). Each identified variant was examined for its association with a wide range of phenotypes and its interactions with glycemic, blood pressure (BP), and lipid controls in incident cardiovascular diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We identified a novel variant (rs10171703) for CHD (odds ratio 1.21 [95% CI 1.13\u20131.30]; P = 2.4 \u00d7 10\u22128) and BP (\u03b2 \u00b1 SE 0.130 \u00b1 0.017; P = 4.1 \u00d7 10\u221214) at PDE1A in Chinese T2D patients but found only a modest association with CHD in general populations. This variant modulated the effects of BP goal attainment (130\/80 mmHg) on CHD (Pinteraction = 0.0155) and myocardial infarction (MI) (Pinteraction = 5.1 \u00d7 10\u22124). Patients with CC genotype of rs10171703 had &amp;gt;40% reduction in either cardiovascular events in response to BP control (2.9 \u00d7 10\u22128 &amp;lt; P &amp;lt; 3.6 \u00d7 10\u22125), those with CT genotype had no difference (0.0726 &amp;lt; P &amp;lt; 0.2614), and those with TT genotype had a threefold increase in MI risk (P = 6.7 \u00d7 10\u22123).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>We discovered a novel CHD- and BP-related variant at PDE1A that interacted with BP goal attainment with divergent effects on CHD risk in Chinese patients with T2D. Incorporating this information may facilitate individualized treatment strategies for precision care in diabetes, only when our findings are validated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc22-2331","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T10:17:52Z","timestamp":1682936272000},"page":"1271-1281","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":13,"title":["Identification of a Common Variant for Coronary Heart Disease at\n                    <i>PDE1A<\/i>\n                    Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes"],"prefix":"10.2337","volume":"46","author":[{"given":"Claudia H.T.","family":"Tam","sequence":"first","affiliation":[{"name":"1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong"},{"name":"2Hong Kong 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