{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:16:53Z","timestamp":1782281813006,"version":"3.54.5"},"reference-count":20,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Ludwig Boltzmann Institute of Aging Research Vienna, Austria"},{"DOI":"10.13039\/100018872","name":"Italian Society of Arterial Hypertension","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018872","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swiss Heart Foundation","award":["FF19045"],"award-info":[{"award-number":["FF19045"]}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["310030_197557"],"award-info":[{"award-number":["310030_197557"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012545","name":"Stiftung f\u00fcr wissenschaftliche Forschung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012545","id-type":"DOI","asserted-by":"crossref"}]},{"name":"H.H. Sheikh Khalifa bin Hamad Al Thani Foundation"},{"DOI":"10.13039\/501100017295","name":"Holcim Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100017295","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kurt und Senta-Hermann Stiftung"},{"DOI":"10.13039\/501100008464","name":"EMDO Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008464","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013161","name":"Swiss Life Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013161","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008473","name":"Gebauer Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008473","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012654","name":"Olga Mayenfisch Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012654","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lindenhof Foundation"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models, yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A preselected panel of lncRNAs was measured in serum of individuals without diabetes (n = 296) from the Vienna Transdanube Aging study, a prospective community-based cohort study. Participants were followed up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (n = 90) was used to validate our findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to hemoglobin A1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>We found a set of circulating lncRNAs that independently portends incident type 2 diabetes in older adults years before disease onset.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc23-0012","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T18:27:35Z","timestamp":1681237655000},"page":"1239-1244","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis From the VITA Cohort Study"],"prefix":"10.2337","volume":"46","author":[{"given":"Florian A.","family":"Wenzl","sequence":"first","affiliation":[{"name":"1Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-9725","authenticated-orcid":false,"given":"Alessandro","family":"Mengozzi","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"},{"name":"4Scuola Superiore Sant\u2019Anna, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafeeq A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Riccardo","family":"Pugliese","sequence":"additional","affiliation":[{"name":"3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Mongelli","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Era","family":"Gorica","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Riederer","sequence":"additional","affiliation":[{"name":"5Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fischer","sequence":"additional","affiliation":[{"name":"6Department of Psychiatry, Medical Research Society Vienna D.C., Danube Hospital Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta","family":"Hinterberger","sequence":"additional","affiliation":[{"name":"6Department of Psychiatry, Medical Research Society Vienna D.C., Danube Hospital Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yustina","family":"Puspitasari","sequence":"additional","affiliation":[{"name":"1Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"1Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland"},{"name":"7Royal Brompton and Harefield Hospitals and Imperial College, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni G.","family":"Camici","sequence":"additional","affiliation":[{"name":"1Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland"},{"name":"8Department of Research and Education, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Matter","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"9University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Fadini","sequence":"additional","affiliation":[{"name":"10University of Padua, Department of Medicine, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Virdis","sequence":"additional","affiliation":[{"name":"3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Masi","sequence":"additional","affiliation":[{"name":"3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"},{"name":"11Institute of Cardiovascular Science, University College London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"9University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Gr\u00fcnblatt","sequence":"additional","affiliation":[{"name":"12Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"13Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland"},{"name":"14Neuroscience Center Zurich, University of Zurich and ETH, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Paneni","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"8Department of Research and Education, University Hospital Zurich, Zurich, Switzerland"},{"name":"9University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Costantino","sequence":"additional","affiliation":[{"name":"2Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"},{"name":"9University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"2023052319013867900_B1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41574-021-00512-2","article-title":"Type 2 diabetes mellitus in older adults: clinical considerations and management","volume":"17","author":"Bellary","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2023052319013867900_B2","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0140-6736(22)01655-5","article-title":"Type 2 diabetes","volume":"400","author":"Ahmad","year":"2022","journal-title":"Lancet"},{"key":"2023052319013867900_B3","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.2337\/dc12-1801","article-title":"Diabetes in older adults","volume":"35","author":"Kirkman","year":"2012","journal-title":"Diabetes Care"},{"key":"2023052319013867900_B4","doi-asserted-by":"crossref","first-page":"602597","DOI":"10.3389\/fendo.2021.602597","article-title":"The Impact of lncRNAs in diabetes mellitus: a systematic review and in silico analyses","volume":"12","author":"Dieter","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2023052319013867900_B5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2023052319013867900_B6","doi-asserted-by":"crossref","first-page":"610213","DOI":"10.3389\/fendo.2020.610213","article-title":"Long non-coding RNAs as key modulators of pancreatic \u03b2-cell mass and function","volume":"11","author":"L\u00f3pez-Noriega","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2023052319013867900_B7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-7091-6139-5_11","article-title":"Vienna Transdanube Aging \u201cVITA\u201d: study design, recruitment strategies and level of participation","author":"Fischer","year":"2002","journal-title":"J Neural Transm Suppl"},{"key":"2023052319013867900_B8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1017\/S1041610209008904","article-title":"Screening for Alzheimer\u2019s dementia at age 78 with short psychometric instruments","volume":"21","author":"Jungwirth","year":"2009","journal-title":"Int Psychogeriatr"},{"key":"2023052319013867900_B9","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1002\/ejhf.2337","article-title":"Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure","volume":"23","author":"Pugliese","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2023052319013867900_B10","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.jcmg.2022.03.024","article-title":"Ventricular-arterial coupling derived from proximal aortic stiffness and\u00a0aerobic capacity across the\u00a0heart\u00a0failure spectrum","volume":"15","author":"Pugliese","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"2023052319013867900_B11","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.2337\/dc20-S002","article-title":"2. Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes-2020","volume":"43","author":"American Diabetes Association","year":"2020","journal-title":"Diabetes Care"},{"key":"2023052319013867900_B12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cmet.2016.11.016","article-title":"Human pancreatic \u03b2 cell lncRNAs control cell-specific regulatory networks","volume":"25","author":"Akerman","year":"2017","journal-title":"Cell Metab"},{"key":"2023052319013867900_B13","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.eprac.2021.04.003","article-title":"Using a diabetes risk score to identify patients without diabetes at risk for new hyperglycemia in the hospital","volume":"27","author":"Mendez","year":"2021","journal-title":"Endocr Pract"},{"key":"2023052319013867900_B14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40246-018-0173-3","article-title":"Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes","volume":"12","author":"Sathishkumar","year":"2018","journal-title":"Hum Genomics"},{"key":"2023052319013867900_B15","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00417-019-04409-9","article-title":"Deciphering the role of circulating lncRNAs: RNCR2, NEAT2, CDKN2B-AS1, and PVT1 and the possible prediction of anti-VEGF treatment outcomes in diabetic retinopathy patients","volume":"257","author":"Toraih","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2023052319013867900_B16","doi-asserted-by":"crossref","first-page":"37354","DOI":"10.1038\/srep37354","article-title":"Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes","volume":"6","author":"de Gonzalo-Calvo","year":"2016","journal-title":"Sci Rep"},{"key":"2023052319013867900_B17","doi-asserted-by":"crossref","first-page":"e71802","DOI":"10.7554\/eLife.71802","article-title":"Epigenetic scores for the circulating proteome as tools for disease prediction","volume":"11","author":"Gadd","year":"2022","journal-title":"eLife"},{"key":"2023052319013867900_B18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1080\/15592294.2016.1178418","article-title":"DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk","volume":"11","author":"Dayeh","year":"2016","journal-title":"Epigenetics"},{"key":"2023052319013867900_B19","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1007\/s10753-020-01282-1","article-title":"LncRNA ANRIL silencing alleviates high glucose-induced inflammation, oxidative stress, and apoptosis via upregulation of MME in podocytes","volume":"43","author":"Cai","year":"2020","journal-title":"Inflammation"},{"key":"2023052319013867900_B20","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1161\/CIRCRESAHA.116.305510","article-title":"lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA","volume":"116","author":"Yan","year":"2015","journal-title":"Circ Res"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/46\/6\/1239\/704595\/dc230012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/46\/6\/1239\/704595\/dc230012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T19:03:22Z","timestamp":1684868602000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/46\/6\/1239\/148707\/Circulating-Long-Noncoding-RNA-Signatures"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,11]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,4,11]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc23-0012","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,11]]}}}