{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:17:57Z","timestamp":1791883077815,"version":"4.3.4"},"reference-count":25,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","award":["G-2204-05196"],"award-info":[{"award-number":["G-2204-05196"]}],"id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK120358"],"award-info":[{"award-number":["R01DK120358"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>There are no commercially available hybrid closed-loop insulin delivery systems customized to achieve pregnancy-specific glucose targets in the U.S. This study aimed to evaluate the feasibility and performance of at-home use of a zone model predictive controller\u2013based closed-loop insulin delivery system customized for pregnancies complicated by type 1 diabetes (CLC-P).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Pregnant women with type 1 diabetes using insulin pumps were enrolled in the second or early third trimester. After study sensor wear collecting run-in data on personal pump therapy and 2 days of supervised training, participants used CLC-P targeting 80\u2013110 mg\/dL during the day and 80\u2013100 mg\/dL overnight running on an unlocked smartphone at home. Meals and activities were unrestricted throughout the trial. The primary outcome was the continuous glucose monitoring percentage of time in the target range 63\u2013140 mg\/dL versus run-in.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Ten participants (HbA1c 5.8 \u00b1 0.6%) used the system from mean gestational age of 23.7 \u00b1 3.5 weeks. Mean percentage time in range increased 14.1 percentage points, equivalent to 3.4 h per day, compared with run-in (run-in 64.5 \u00b1 16.3% versus CLC-P 78.6 \u00b1 9.2%; P = 0.002). During CLC-P use, there was significant decrease in both time over 140 mg\/dL (P = 0.033) and the hypoglycemic ranges of less than 63 mg\/dL and 54 mg\/dL (P = 0.037 for both). Nine participants exceeded consensus goals of above 70% time in range during CLC-P use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The results show that the extended use of CLC-P at home until delivery is feasible. Larger, randomized studies are needed to further evaluate system efficacy and pregnancy outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc23-0173","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T21:10:14Z","timestamp":1684357814000},"page":"1425-1431","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":45,"title":["At-Home Use of a Pregnancy-Specific Zone-MPC Closed-Loop System for Pregnancies Complicated by Type 1 Diabetes: A Single-Arm, Observational Multicenter Study"],"prefix":"10.2337","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-2578","authenticated-orcid":false,"given":"Carol J.","family":"Levy","sequence":"first","affiliation":[{"name":"1Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogish C.","family":"Kudva","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Ozaslan","sequence":"additional","affiliation":[{"name":"3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA"},{"name":"4Sansum Diabetes Research Institute, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Castorino","sequence":"additional","affiliation":[{"name":"4Sansum Diabetes Research Institute, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grenye","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"1Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder Jeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla M.","family":"Levister","sequence":"additional","affiliation":[{"name":"1Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Mei","family":"Church","sequence":"additional","affiliation":[{"name":"4Sansum Diabetes Research Institute, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Desjardins","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"McCrady-Spitzer","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selassie","family":"Ogyaadu","sequence":"additional","affiliation":[{"name":"1Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari Charisse","family":"Trinidad","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Reid","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafaq","family":"Rizvi","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Deshpande","sequence":"additional","affiliation":[{"name":"3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA"},{"name":"4Sansum Diabetes Research Institute, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Zaniletti","sequence":"additional","affiliation":[{"name":"5Mayo Clinic, Scottsdale, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter K.","family":"Kremers","sequence":"additional","affiliation":[{"name":"2Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Pinsker","sequence":"additional","affiliation":[{"name":"4Sansum Diabetes Research Institute, Santa Barbara, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Francis J.","family":"Doyle","sequence":"additional","affiliation":[{"name":"3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-6892","authenticated-orcid":false,"given":"Eyal","family":"Dassau","sequence":"additional","affiliation":[{"name":"3Harvard John A. 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