{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:11:05Z","timestamp":1790871065513,"version":"4.1.0"},"reference-count":24,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100009881","name":"Juvenile Diabetes Research Foundation Canada","doi-asserted-by":"publisher","award":["4-SRA-2018-651-Q-R"],"award-info":[{"award-number":["4-SRA-2018-651-Q-R"]}],"id":[{"id":"10.13039\/100009881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["JT1-157204"],"award-info":[{"award-number":["JT1-157204"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>Current guidelines recommend initiating treatment for nonsevere (NS) hypoglycemia with 15 g carbohydrates (CHO) at 15-min intervals when blood glucose (BG) reaches &amp;lt;70 mg\/dL (3.9 mmol\/L). Despite this recommendation, NS hypoglycemia management remains challenging for individuals living with type 1 diabetes (T1D). We aimed to assess the efficacy of 15 g CHO at higher BG levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>A total of 29 individuals with T1D participated in an open-label crossover study. After an inpatient subcutaneous insulin-induced decrease in BG in the fasting state, 16 g CHO was administered orally at a plasma glucose (PG) of &amp;lt;70 (3.9), \u226480 (4.5), or \u226490 mg\/dL (5.0 mmol\/L). The primary outcome was time spent in hypoglycemia (&amp;lt;70 mg\/dL) after initial CHO intake.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>When comparing the &amp;lt;70 (control) with the \u226480 and \u226490 mg\/dL treatment groups, 100 vs. 86 (P = 0.1201) vs. 34% (P &amp;lt; 0.0001) of participants reached hypoglycemia, respectively. These hypoglycemic events lasted 26.0 \u00b1 12.6 vs. 17.9 \u00b1 14.7 (P = 0.026) vs. 7.1 \u00b1 11.8 min (P = 0.002), with a PG nadir of 56.57 \u00b1 9.91 vs. 63.60 \u00b1 7.93 (P = 0.008) vs. 73.51 \u00b1 9.37 mg\/dL (P = 0.002), respectively. In the control group, 69% of participants required more than one treatment to reach or maintain normoglycemia (\u226570 mg\/dL), compared with 52% in the \u226480 mg\/dL group and 31% in the \u226490 mg\/dL group, with no significant rebound hyperglycemia (&amp;gt;180 mg\/dL) within the first hour.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>For some impending NS hypoglycemia episodes, individuals with TID could benefit from CHO intake at a higher BG level.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc23-1328","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T20:58:25Z","timestamp":1704833905000},"page":"476-482","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":12,"title":["Managing Impending Nonsevere Hypoglycemia With Oral Carbohydrates in Type 1 Diabetes: The REVERSIBLE Trial"],"prefix":"10.2337","volume":"47","author":[{"given":"Ran","family":"Cheng","sequence":"first","affiliation":[{"name":"1Institut de recherches cliniques de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"2Department of Biomedical Sciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"3Endocrinology Division, H\u00f4pital Maisonneuve-Rosemont, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"4Endocrinology Division, H\u00f4pital Santa-Cabrini, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-430X","authenticated-orcid":false,"given":"Nadine","family":"Taleb","sequence":"additional","affiliation":[{"name":"1Institut de recherches cliniques de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"5Endocrinology Division, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Lalanne-Mistrih","sequence":"additional","affiliation":[{"name":"1Institut de recherches cliniques de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Boudreau","sequence":"additional","affiliation":[{"name":"1Institut de recherches cliniques de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Messier","sequence":"additional","affiliation":[{"name":"1Institut de recherches cliniques de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9e","family":"Lacombe","sequence":"additional","affiliation":[{"name":"1Institut de recherches cliniques de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, 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