{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:54:01Z","timestamp":1769050441569,"version":"3.49.0"},"reference-count":20,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K08DK103945"],"award-info":[{"award-number":["K08DK103945"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R03DK122100"],"award-info":[{"award-number":["R03DK122100"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To identify plasma miRNAs related to treatment failure in youth with type 2 diabetes (T2D).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We examined whether a panel of miRNAs could predict treatment failure in training\/test data sets among participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study (N = 209). We also examined whether individual miRNAs were associated with treatment failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Participants were age 14.5 years, and 62% were female. A panel of miRNAs did not predict treatment failure. However, for each doubling, miR-4306 was associated with a 12% decrease (P = 0.040) and miR-483-3p was marginally associated with a 12% increase (P = 0.080) in failure independently of sex, race\/ethnicity, BMI, Tanner stage, HbA1c, maternal diabetes, oral disposition index, and treatment arm. The addition of both miRNAs improved model fit (log likelihood without vs. with miRNAs \u2212360.3 vs. \u2212363.5; P = 0.040).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>miR-483-3p and miR-4306 may be associated with treatment failure in youth with T2D.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc23-1540","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T17:56:10Z","timestamp":1703786170000},"page":"471-475","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":6,"title":["Plasma miRNAs and Treatment Failure in Participants in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study"],"prefix":"10.2337","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-1464","authenticated-orcid":false,"given":"Pandora L.","family":"Wander","sequence":"first","affiliation":[{"name":"1Veterans Affairs Puget Sound Health Care System, Seattle, WA"},{"name":"2Department of Medicine, University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo K.","family":"Bammler","sequence":"additional","affiliation":[{"name":"3Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"3Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sengeo","family":"Srinouanprachanh","sequence":"additional","affiliation":[{"name":"3Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Boyko","sequence":"additional","affiliation":[{"name":"1Veterans Affairs Puget Sound Health Care System, Seattle, WA"},{"name":"2Department of Medicine, University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Enquobahrie","sequence":"additional","affiliation":[{"name":"4Department of Epidemiology, University of Washington, Seattle, WA"},{"name":"5Department of Health Systems and Population Health, University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"2024022320554668300_B1","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1056\/NEJMoa1109333","article-title":"A clinical trial to maintain glycemic control in youth with type 2 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