{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:23:08Z","timestamp":1771464188048,"version":"3.50.1"},"reference-count":7,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103908"],"award-info":[{"award-number":["82103908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shuimu Scholar Program of Tsinghua University, National Postdoctoral Innovative Talent Support Program","award":["BX20230189"],"award-info":[{"award-number":["BX20230189"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QH014"],"award-info":[{"award-number":["ZR2021QH014"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54-AG065141"],"award-info":[{"award-number":["U54-AG065141"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54-HL169191"],"award-info":[{"award-number":["U54-HL169191"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54-HL170326"],"award-info":[{"award-number":["U54-HL170326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To investigate whether the sex disparities in type 2 diabetes\u2013associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We analyzed intensive versus standard BP control in relation to incident CVD events in women and men with type 2 diabetes, based on their age of hypertension diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 3,792 adults with type 2 diabetes (49% women), multivariable-adjusted CVD risk was increased per decade earlier age at hypertension diagnosis (hazard ratio 1.11 [1.03\u20131.21], P = 0.006). Excess risk associated with early-diagnosed hypertension was attenuated in the presence of intensive versus standard antihypertensive therapy in women (P = 0.036) but not men (P = 0.76).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Women with type 2 diabetes and early-onset hypertension may represent a higher-risk subpopulation that not only contributes to the excess in diabetes-related CVD risk for women but may benefit from intensive BP control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc23-2275","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T14:02:11Z","timestamp":1713967331000},"page":"1028-1031","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":7,"title":["Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes"],"prefix":"10.2337","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-4666","authenticated-orcid":false,"given":"Hongwei","family":"Ji","sequence":"first","affiliation":[{"name":"1Tsinghua Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Ebinger","sequence":"additional","affiliation":[{"name":"2Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan C.","family":"Kwan","sequence":"additional","affiliation":[{"name":"2Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Reue","sequence":"additional","affiliation":[{"name":"3Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"4Department of Physiology, Augusta University, Augusta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Shyy","sequence":"additional","affiliation":[{"name":"5Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4977-036X","authenticated-orcid":false,"given":"Susan","family":"Cheng","sequence":"additional","affiliation":[{"name":"2Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"2024052018524323800_B1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11906-015-0554-0","article-title":"Excess cardiovascular risk in diabetic women: a case for intensive treatment","volume":"17","author":"Recarti","year":"2015","journal-title":"Curr Hypertens Rep"},{"key":"2024052018524323800_B2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jama.2014.18574","article-title":"Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis","volume":"313","author":"Emdin","year":"2015","journal-title":"JAMA"},{"key":"2024052018524323800_B3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/jamacardio.2019.5306","article-title":"Sex differences in blood pressure trajectories over the life course","volume":"5","author":"Ji","year":"2020","journal-title":"JAMA Cardiol"},{"key":"2024052018524323800_B4","doi-asserted-by":"crossref","first-page":"e021922","DOI":"10.1161\/JAHA.121.021922","article-title":"Sex differences in cumulative exposure to metabolic risk factors before hypertension onset: the cohort of the Tehran Lipid and Glucose Study","volume":"10","author":"Ramezankhani","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2024052018524323800_B5","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1001286","article-title":"Effects of intensive blood-pressure control in type 2 diabetes mellitus","volume":"362","author":"Cushman","year":"2010","journal-title":"N Engl J Med"},{"key":"2024052018524323800_B6","doi-asserted-by":"crossref","first-page":"j1949","DOI":"10.1136\/bmj.j1949","article-title":"Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study","volume":"357","author":"Niiranen","year":"2017","journal-title":"BMJ"},{"key":"2024052018524323800_B7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/HYPERTENSIONAHA.119.13820","article-title":"Investigation and treatment of high blood pressure in young people: too much medicine or appropriate risk reduction?","volume":"75","author":"Hinton","year":"2020","journal-title":"Hypertension"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/47\/6\/1028\/764711\/dc232275.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/47\/6\/1028\/764711\/dc232275.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T18:55:24Z","timestamp":1716231324000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/47\/6\/1028\/154514\/Early-Onset-Hypertension-and-Sex-Specific-Residual"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,4,24]]},"published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc23-2275","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]}}}