{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:25:47Z","timestamp":1784291147118,"version":"3.55.0"},"reference-count":20,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN275200800013C, HHSN275200800002I, HHSN27500006"],"award-info":[{"award-number":["HHSN275200800013C, HHSN275200800002I, HHSN27500006"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["Intramural research program"],"award-info":[{"award-number":["Intramural research program"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To investigate associations of plasma glycated albumin (GA) concentrations in early and midpregnancy with gestational diabetes mellitus (GDM) risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We measured GA concentrations using blood samples collected at 10\u201314 and 15\u201326 weeks\u2019 gestation in 107 GDM case and 214 control participants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Study. We performed generalized linear mixed-effect regression to test the mean GA difference between GDM case and control participants and conditional logistic regression to assess prospective associations between GA concentrations and GDM risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>At 15\u201326 weeks\u2019 gestation mean GA was lower in GDM case participants than in control participants (mean 11.90% [95% CI 6.42\u201332.76] vs. 12.46% [8.45\u201338.35], adjusted P value for difference = 0.004). Consistently, women with higher GA concentrations tended to have a lower GDM risk, although the associations were not statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This study suggests that GA concentrations in midpregnancy might be lower in women who later develop GDM. Further studies are needed to identify the mechanism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc24-0668","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T18:47:41Z","timestamp":1720205261000},"page":"1593-1596","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective and Longitudinal Study"],"prefix":"10.2337","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-4094","authenticated-orcid":false,"given":"Justine","family":"Cole","sequence":"first","affiliation":[{"name":"1Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-6954","authenticated-orcid":false,"given":"Claire","family":"Guivarch","sequence":"additional","affiliation":[{"name":"2Global Centre for Asian Women\u2019s Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"3Bia-Echo Asia Centre for Reproductive Longevity & Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"4Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"5Glotech Inc., Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Stallcup","sequence":"additional","affiliation":[{"name":"1Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-7022","authenticated-orcid":false,"given":"Wei Wei","family":"Pang","sequence":"additional","affiliation":[{"name":"2Global Centre for Asian Women\u2019s Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"3Bia-Echo Asia Centre for Reproductive Longevity & Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"4Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8014-2708","authenticated-orcid":false,"given":"Cuilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Global Centre for Asian Women\u2019s Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"3Bia-Echo Asia Centre for Reproductive Longevity & Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"4Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"6Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-0735","authenticated-orcid":false,"given":"David B.","family":"Sacks","sequence":"additional","affiliation":[{"name":"1Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"2024082720362069900_B1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2337\/diab.34.2.S119","article-title":"Gestational diabetes mellitus and impaired glucose tolerance during pregnancy. 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