{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:47:34Z","timestamp":1790880454233,"version":"4.1.0"},"reference-count":18,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To assess the accuracy of \u201cdiabetes overtreatment\u201d proxy definitions in predicting hypoglycemia in older adults with type 2 diabetes (T2D).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Inclusion of patients from HYPOAGE cohort with insulin-treated T2D, aged \u226575 years, and using a continuous glycemic monitoring (CGM) device for 28 days. \u201cDiabetes overtreatment\u201d was defined as HbA1c &amp;lt;7.0% (fixed proxy definition) or as HbA1c &amp;lt;7.0%, 7.5%, and 8.0% according to patient\u2019s health status (individualized proxy definition). The primary outcome was time below range (TBR) \u22651%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 134 patients included (81.6 \u00b1 5.4 years, 59% male), 25 (19%) and 53 (40%) were overtreated, based on fixed and individualized proxy definitions, respectively. CGM data showed TBR &amp;gt;1% in nearly all patients regardless of overtreatment status. Both proxy definitions had low sensitivity (20% [14; 29] and 41% [32; 50]) and accuracy (27% [20; 35] and 44% [35; 53]) in predicting hypoglycemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A revised definition of diabetes overtreatment is needed to better manage older insulin-treated patients and protect them from hypoglycemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc24-1058","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T18:36:28Z","timestamp":1724351788000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":11,"title":["Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort 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