{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:39:45Z","timestamp":1793659185646,"version":"4.5.1"},"reference-count":33,"publisher":"American Diabetes Association","issue":"12","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["APP1194510"],"award-info":[{"award-number":["APP1194510"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To prospectively examine the association between device-measured sleep regularity and incidence of type 2 diabetes (T2D) in a population-based sample of adults. We also examined if meeting sleep duration recommendations attenuated or eliminated the effects of irregular sleep on T2D.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We conducted a prospective cohort study of adults aged 40\u201379 years participating in the UK Biobank accelerometer substudy. Participants wore wrist-attached accelerometers for a duration of 7 days, which was used to compute the Sleep Regularity Index (SRI). Participants were categorized as irregular (SRI &amp;lt;71.6), moderately irregular (SRI between 71.6 and 87.3), and regular (SRI &amp;gt;87.3) sleepers. T2D diagnosis was obtained through self-reports and health records.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We analyzed data from 73,630 individuals observed for 8 years, without a history of T2D and without an event in the first year of follow-up. Compared with regular sleepers, irregular (hazard ratio [HR] 1.38; 95% CI 1.20\u20131.59) and moderately irregular sleepers (HR 1.35; 95% CI 1.19\u20131.53) were at higher risk of T2D incidence. Dose-response analyses treating SRI as a continuous measure showed higher T2D incidence with SRI scores &amp;lt;80. Meeting current sleep duration recommendations did not counteract the adverse effects of irregular (HR 1.35; 95% CI 1.09\u20131.66) or moderately irregular (HR 1.29; 95% CI 1.08\u20131.54) sleep on T2D incidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Moderate and high sleep irregularity were deleteriously associated with T2D risk, even in participants who slept \u22657 h per night. Future sleep interventions will need to pay more attention to consistency in bedtimes and wake-up times, in addition to sleep duration and quality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc24-1208","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T16:26:22Z","timestamp":1728577582000},"page":"2139-2145","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":47,"title":["Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults"],"prefix":"10.2337","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-5736","authenticated-orcid":false,"given":"Jean-Philippe","family":"Chaput","sequence":"first","affiliation":[{"name":"1Healthy Active Living and Obesity Research Group, Children\u2019s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada"},{"name":"2Department of Pediatrics, Faculty of Medicine, 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