{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:28:57Z","timestamp":1788222537456,"version":"build-2803163510"},"reference-count":33,"publisher":"American Diabetes Association","issue":"12","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100014592","name":"Insulet Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To examine the efficacy and safety of the tubeless Omnipod 5 automated insulin delivery (AID) system compared with pump therapy with a continuous glucose monitor (CGM) in adults with type 1 diabetes with suboptimal glycemic outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>In this 13-week multicenter, parallel-group, randomized controlled trial performed in the U.S. and France, adults aged 18\u201370 years with type 1 diabetes and HbA1c 7\u201311% (53\u201397 mmol\/mol) were randomly assigned (2:1) to intervention (tubeless AID) or control (pump therapy with CGM) following a 2-week standard therapy period. The primary outcome was a treatment group comparison of time in range (TIR) (70\u2013180 mg\/dL) during the trial period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 194 participants were randomized, with 132 assigned to the intervention and 62 to the control. TIR during the trial was 4.2h\/day higher in the intervention compared with the control group (mean difference 17.5% [95% CI 14.0%, 21.1%]; P &amp;lt; 0.0001). The intervention group had a greater reduction in HbA1c from baseline compared with the control group (mean \u00b1 SD \u22121.24 \u00b1 0.75% [\u221213.6 \u00b1 8.2 mmol\/mol] vs. \u22120.68 \u00b1 0.93% [\u22127.4 \u00b1 10.2 mmol\/mol], respectively; P &amp;lt; 0.0001), accompanied by a significantly lower time &amp;lt;70 mg\/dL (1.18 \u00b1 0.86% vs. 1.75 \u00b1 1.68%; P = 0.005) and &amp;gt;180 mg\/dL (37.6 \u00b1 11.4% vs. 54.5 \u00b1 15.4%; P &amp;lt; 0.0001). All primary and secondary outcomes were met. No instances of diabetes-related ketoacidosis or severe hypoglycemia occurred in the intervention group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Use of the tubeless AID system led to improved glycemic outcomes compared with pump therapy with CGM among adults with type 1 diabetes, underscoring the clinical benefit of AID and bolstering recommendations to establish AID systems as preferred therapy for this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc24-1550","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T16:25:06Z","timestamp":1729268706000},"page":"2248-2257","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy and Safety of a Tubeless AID System Compared With Pump Therapy With CGM in the Treatment of Type 1 Diabetes in Adults With Suboptimal Glycemia: A Randomized, Parallel-Group Clinical Trial"],"prefix":"10.2337","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-7263","authenticated-orcid":false,"given":"Eric","family":"Renard","sequence":"first","affiliation":[{"name":"1Department of Endocrinology and Diabetes, Montpellier University Hospital; INSERM CIC1411 Clinical Investigation Center, Institute of Functional Genomics, CNRS, INSERM, University of Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-5666","authenticated-orcid":false,"given":"Ruth S.","family":"Weinstock","sequence":"additional","affiliation":[{"name":"2Department of Medicine, SUNY Upstate Medical University, Syracuse, 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