{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:02:07Z","timestamp":1791669727075,"version":"4.3.4"},"reference-count":15,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Dexcom Inc"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate whether continuous glucose monitoring (CGM) could assist providers in intensifying glycemic management in hospitalized patients with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>At six academic hospitals, adults with type 2 diabetes hospitalized in a non\u2013intensive care setting were randomly assigned to either standard therapy with glucose target 140\u2013180 mg\/dL (standard group) or intensive therapy with glucose target 90\u2013130 mg\/dL guided by CGM (intensive group). The primary outcome was mean glucose measured with CGM (blinded in standard group), and the key secondary outcome was CGM glucose &amp;lt;54 mg\/dL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>For the 110 participants included in the primary analysis, mean \u00b1 SD age was 61 \u00b1 12 years and mean HbA1c was 8.9 \u00b1 2.3% (73.8 \u00b1 1.6 mmol\/mol). During the study, CGM-measured mean glucose was 170 mg\/dL for the intensive group (n = 60) vs. 175 mg\/dL for the standard group (n = 50; risk-adjusted difference \u22127 mg\/dL, 95% CI \u221219 to 5; P = 0.25). Only 7% of the intensive group achieved the mean glucose target range of 90\u2013130 mg\/dL. CGM readings &amp;lt;54 mg\/dL were infrequent (0.2% for intensive and 0.4% for standard; adjusted treatment group difference \u22120.1%, 95% CI \u22120.6 to 0.3). One severe hypoglycemia event occurred in the standard group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The study\u2019s glucose management approach using CGM did not improve glucose levels compared with standard glucose management in the non\u2013intensive care unit hospital setting. A glucose target of 90\u2013130 mg\/dL may not be realistic in the current environment of insulin management in the hospital.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc24-1779","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T15:48:03Z","timestamp":1732204083000},"page":"118-124","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":26,"title":["Results From a Randomized Trial of Intensive Glucose Management Using CGM Versus Usual Care in Hospitalized Adults With Type 2 Diabetes: The TIGHT Study"],"prefix":"10.2337","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-8417","authenticated-orcid":false,"given":"Irl B.","family":"Hirsch","sequence":"first","affiliation":[{"name":"1University of Washington, Seattle, 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