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Mean \u00b1 SD HbA1c was 7.57% \u00b1 0.97% at baseline and 7.62% \u00b1 1.06% at 17 weeks in the TI group and 7.59% \u00b1 0.80% and 7.54% \u00b1 0.77%, respectively, in the UC group (adjusted difference 0.11%, 95% CI \u22120.10 to 0.33, P value for noninferiority = 0.01). HbA1c improved from baseline to 17 weeks by &amp;gt;0.5% (5.5 mmol\/mol) in 12 (21%) in the TI group and in 3 (5%) in the UC group and worsened by &amp;gt;0.5% (5.5 mmol\/mol) in 15 (26%) in the TI group and in 2 (3%) in the UC group. The most common TI side effect was a brief cough; eight participants discontinued TI due to side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In adults with type 1 diabetes, HbA1c after 17 weeks with a regimen of TI and degludec was noninferior to UC, which consisted predominately of either AID or MDI. TI should be considered an option for people with type 1 diabetes, particularly those who are motivated to further reduce postprandial hyperglycemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc24-1832","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T11:38:41Z","timestamp":1733485121000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":25,"title":["A Randomized Trial Comparing Inhaled Insulin Plus Basal Insulin Versus Usual Care in Adults With Type 1 Diabetes"],"prefix":"10.2337","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-8417","authenticated-orcid":false,"given":"Irl B.","family":"Hirsch","sequence":"first","affiliation":[{"name":"1University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-8446","authenticated-orcid":false,"given":"Roy 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