{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:57:15Z","timestamp":1789016235261,"version":"build-2803163510"},"reference-count":36,"publisher":"American Diabetes Association","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1R01DK127208-01,1UC4DK108173"],"award-info":[{"award-number":["1R01DK127208-01,1UC4DK108173"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","award":["Arnold W Strauss Award"],"award-info":[{"award-number":["Arnold W Strauss Award"]}],"id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Molecular Epidemiology in Children's Environmental Health Training Program","award":["T32 ES010957"],"award-info":[{"award-number":["T32 ES010957"]}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["DP-15-002, DP-05-069, DP-10-001"],"award-info":[{"award-number":["DP-15-002, DP-05-069, DP-10-001"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents and young adults with youth-onset diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>This study included 1,226 individuals (median age at initial visit 18 years; 58% female; 53% non-Hispanic White, 22% non-Hispanic Black, and 20% Hispanic) with youth-onset type 1 or type 2 diabetes from the SEARCH for Diabetes in Youth Study. Arterial stiffness measures included pulse wave velocity for carotid femoral, carotid radial, femoral foot, and augmentation index (AIx). Microvascular complications included microalbuminuria, peripheral neuropathy, and retinopathy. Participants were followed up once at \u223c5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Cross-sectionally, in type 1 diabetes, AIx was associated with higher odds of having any one microvascular complication (odds ratio [OR] 1.35; 95% CI 1.04\u20131.76), microalbuminuria (OR 2.76; 95% CI 1.78\u20134.39), neuropathy (OR 1.63; 95% CI 1.07\u20132.50), and retinopathy (OR 1.37; 95% CI 1.06\u20131.79). In type 2 diabetes, AIx was associated with higher odds of microalbuminuria (OR 2.05; 95% CI 1.04\u20134.33; all P &amp;lt; 0.05). In longitudinal analysis, in type 1 diabetes, a change in AIx was associated with the development of any one microvascular complication (OR 1.45; 95% CI 1.15\u20131.82), microalbuminuria (OR 5.42; 95% CI 1.98\u201314.80), neuropathy (OR 2.03; 95% CI 1.22\u20133.40), and retinopathy (OR 1.48; 95% CI 1.15\u20131.90). In type 2 diabetes, a change in AIx was associated with the development of microalbuminuria (OR 21.98; 95% CI 1.30\u2013372.88; all P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Arterial stiffness is related to and predicts microvascular complications in youth-onset type 1 and type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc24-2320","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T10:21:17Z","timestamp":1739528477000},"page":"639-647","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":6,"title":["Arterial Stiffness Is Related to Diabetes-Associated Microvascular Complications: The SEARCH for Diabetes in Youth 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OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Dabelea","sequence":"additional","affiliation":[{"name":"3Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Denver, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lustigova","sequence":"additional","affiliation":[{"name":"4Department of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santica","family":"Marcovina","sequence":"additional","affiliation":[{"name":"5Medpace Reference Laboratories, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Mottl","sequence":"additional","affiliation":[{"name":"6Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Pihoker","sequence":"additional","affiliation":[{"name":"7Department of Pediatrics, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"4Department of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeAnne","family":"Sancrainte","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence M.","family":"Dolan","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center and 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