{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:47Z","timestamp":1753889807365,"version":"3.41.2"},"reference-count":0,"publisher":"American Diabetes Association","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>We assess diabetes risk in adulthood among adolescents with isolated glucosuria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>Included were adolescents (16\u201319 years) examined before military service between 1993 and 2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The study included 1,611,467 adolescents, of whom 755 (0.05%) had glucosuria. The latter group had a higher proportion of males (75% vs. 57%) and a lower proportion of BMI \u2265 85th percentile (10.4% vs. 16.3%) compared with nonglucosuric (all P &amp;lt; 0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with versus without glucosuria, respectively. Individuals with glucosuria had an adjusted hazard ratio of 2.17 (95% CI, 1.17\u20134.04) for diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc24-2402","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T20:37:21Z","timestamp":1740602241000},"update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents"],"prefix":"10.2337","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-8473","authenticated-orcid":false,"given":"Adi","family":"Vinograd","sequence":"first","affiliation":[{"name":"1The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsahi T.","family":"Lerman","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"3Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Pinhas-Hamiel","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"4Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Bardugo","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"5The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel"},{"name":"6Department of Military Medicine, Hebrew University and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cole D.","family":"Bendor","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"5The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel"},{"name":"6Department of Military Medicine, Hebrew University and the Israel Defense Forces Medical Corps, Ramat Gan, Israel"},{"name":"7Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Derazne","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[{"name":"8Optimal Aging Institute and Department of Population Health, Grossman School of Medicine, New York University, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofir","family":"Vinograd","sequence":"additional","affiliation":[{"name":"9Department of Orthopedics, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miri","family":"Lutski","sequence":"additional","affiliation":[{"name":"1The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel"},{"name":"7Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inbar","family":"Zucker","sequence":"additional","affiliation":[{"name":"1The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel"},{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Bromberg","sequence":"additional","affiliation":[{"name":"1The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel"},{"name":"7Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Fishman","sequence":"additional","affiliation":[{"name":"10Pharmacy Services, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[{"name":"7Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hertzel C.","family":"Gerstein","sequence":"additional","affiliation":[{"name":"11Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tali","family":"Cukierman-Yaffe","sequence":"additional","affiliation":[{"name":"7Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"12Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asaf","family":"Vivante","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"13Department of Pediatrics B and Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Leiba","sequence":"additional","affiliation":[{"name":"14Nephrology and Hypertension Institute, Samson Assuta Ashdod University Hospital, Ashdod, Israel"},{"name":"15Faculty of Health Sciences, Joyce & Irving Goldman Medical School at Ben Gurion, University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Afek","sequence":"additional","affiliation":[{"name":"16Central Management, Sheba Medical Center, Ramat Gan, Israel"},{"name":"17The Dina Recanati School of Medicine, Reichman University, Herzliya, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Tirosh","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"12Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Fishman","sequence":"additional","affiliation":[{"name":"2School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"5The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel"},{"name":"18Division of Cardiology, Sheba Medical Center, Ramat Gan, Israel"},{"name":"19The Geriatric Division, University of Pittsburgh Medical Center, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2829-3645","authenticated-orcid":false,"given":"Gilad","family":"Twig","sequence":"additional","affiliation":[{"name":"5The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel"},{"name":"7Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"},{"name":"12Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2025,2,26]]},"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/doi\/10.2337\/dc24-2402\/800333\/dc242402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/doi\/10.2337\/dc24-2402\/800333\/dc242402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T20:37:21Z","timestamp":1740602241000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/doi\/10.2337\/dc24-2402\/157934\/Isolated-Glucosuria-in-Adolescence-and-Early-Onset"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.2337\/dc24-2402","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"type":"print","value":"0149-5992"},{"type":"electronic","value":"1935-5548"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"article-number":"dc242402"}}