{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:29:45Z","timestamp":1777480185884,"version":"3.51.4"},"reference-count":26,"publisher":"American Diabetes Association","issue":"6","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"NIH","award":["P30 DK078392"],"award-info":[{"award-number":["P30 DK078392"]}]},{"name":"NIH","award":["R03 DK 131156"],"award-info":[{"award-number":["R03 DK 131156"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>In children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP), circulating islet autoantibodies (auto-Ab) may influence \u03b2-cell function. This study reports Ab prevalence in youth with ARP or CP and investigates effects on indices of insulin secretion during mixed meal tolerance testing (MMTT) and diabetes status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>This was a retrospective cross-sectional analysis of 234 youth with ARP or CP who had islet Ab testing (Ab+ group, n = 28 [12%]; Ab\u2212 group, n = 206 [88%]). Fasting glucose and HbA1c were collected. MMTT was performed in 78% of participants (183 of 234). MMTT-derived indices were calculated and compared between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The Ab+ and Ab\u2212 groups did not differ in age, sex, race, ethnicity, BMI percentile, or fasting glucose. Of Ab+ patients, 54% had one Ab+ islet and 46% had multiple Ab+ islets. Comparing the Ab+ to Ab\u2212 groups, HbA1c was higher (median 5.7 vs. 5.2%, P &amp;lt; 0.01), and C-peptide was lower (median 2.4 vs. 3.7 ng\/mL, P = 0.01) in the Ab+ group. The Ab+ compared with the Ab\u2212 group had a higher proportion of prediabetes\/diabetes (57% vs. 32%, P &amp;lt; 0.001). In survival analysis, the Ab+ group had significantly shorter time from first acute pancreatitis episode to diabetes development (P = 0.02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In children with ARP or CP, Ab+ was associated with higher risk of diabetes\/diabetes development and shorter time to diabetes development, suggesting that islet Ab+ is associated with \u03b2-cell dysfunction in this patient cohort. Islet Ab+ was also associated with higher HbA1c and lower C-peptide levels. Future studies are needed to validate the role of islet Ab positivity in pancreatitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dc24-2672","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T17:12:16Z","timestamp":1744737136000},"page":"974-981","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["Islet Autoantibodies and Their Association With \u03b2-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis"],"prefix":"10.2337","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5211-4105","authenticated-orcid":false,"given":"Gila","family":"Ginzburg","sequence":"first","affiliation":[{"name":"1Medical College of Wisconsin and Children\u2019s Wisconsin, Milwaukee, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Hornung","sequence":"additional","affiliation":[{"name":"2Division of Biostatistics and Epidemiology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Denson","sequence":"additional","affiliation":[{"name":"3Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH"},{"name":"4Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7297-139X","authenticated-orcid":false,"given":"Amy S.","family":"Shah","sequence":"additional","affiliation":[{"name":"3Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH"},{"name":"5Division of Pediatric Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Swauger","sequence":"additional","affiliation":[{"name":"3Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH"},{"name":"5Division of Pediatric Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Tatum","sequence":"additional","affiliation":[{"name":"5Division of Pediatric Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-0313","authenticated-orcid":false,"given":"Siobhan","family":"Tellez","sequence":"additional","affiliation":[{"name":"5Division of Pediatric Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6417-3619","authenticated-orcid":false,"given":"Deborah","family":"Elder","sequence":"additional","affiliation":[{"name":"3Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH"},{"name":"5Division of Pediatric Endocrinology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7324-4837","authenticated-orcid":false,"given":"Melena D.","family":"Bellin","sequence":"additional","affiliation":[{"name":"6Department of Pediatrics, Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN"},{"name":"7Department of Surgery, Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, 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