{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:53:41Z","timestamp":1781722421338,"version":"3.54.5"},"reference-count":13,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Dr. Mary Papantony Research Fund"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effect of glucagon-like peptide 1 receptor agonist (GLP-1RA) versus dipeptidyl peptidase 4 inhibitor (DPP4i) initiation on emergency department (ED) visits and all-cause hospitalizations across the spectrum of kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>This was a retrospective population-based observational cohort study in adults with an estimated glomerular filtration rate &amp;lt;90 mL\/min\/1.73 m2 using inverse probability of treatment weighting. The Prentice-Williams-Peterson (PWP) gap time model was used for the primary analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The cohort included 24,576 new users of a GLP-1RA and 23,600 DPP4i new users. GLP-1RA initiation was associated with a lower risk of all-cause ED encounters or hospitalizations (hazard ratio [HR] 0.90; 95% CI 0.87\u20130.94; P &amp;lt; 0.0001). This finding was consistent in confirmatory analyses using the Andersen-Gill model and the PWP calendar time model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>GLP-1RA initiation was associated with a reduction in all-cause ED visits and hospitalizations compared with new use of a DPP4i.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc24-2811","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:47:05Z","timestamp":1750942025000},"page":"1524-1528","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Emergency Department Visits and Hospitalization in Patients With Chronic Kidney Disease"],"prefix":"10.2337","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8653-6778","authenticated-orcid":false,"given":"Kevin","family":"Yau","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, St. Michael\u2019s Hospital 1 , Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto 2 , Toronto, Ontario, Canada"},{"name":"Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital 3 , Toronto, Ontario, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto 4 , Toronto, Ontario, Canada"},{"name":"Division of Nephrology, Department of Medicine, University Health Network, University of Toronto 5 , Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel G.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto 2 , Toronto, Ontario, Canada"},{"name":"Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital 3 , Toronto, Ontario, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto 4 , Toronto, Ontario, Canada"},{"name":"Department of Obstetrics and Gynaecology, St. Michael\u2019s Hospital, University of Toronto 6 , Toronto, Ontario, Canada"},{"name":"Child Health Evaluative Sciences, SickKids Research Institute, Toronto 7 , Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivethika","family":"Jeyakumar","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute, London Health Sciences Centre 8 , London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute, London Health Sciences Centre 8 , London, Ontario, Canada"},{"name":"ICES, Toronto 9 , Ontario, 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London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Castrillon-Ramirez","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute, London Health Sciences Centre 8 , London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Udell","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto 2 , Toronto, Ontario, Canada"},{"name":"Women\u2019s College Hospital and Peter Munk Cardiac Centre, Toronto General Hospital 12 , Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Meraz-Munoz","sequence":"additional","affiliation":[{"name":"University of Manitoba Max Rady College of Medicine 13 , Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, St. Michael\u2019s Hospital 1 , Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto 2 , Toronto, Ontario, Canada"},{"name":"Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital 3 , Toronto, Ontario, Canada"},{"name":"ICES, Toronto 9 , Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Harel","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, St. Michael\u2019s Hospital 1 , Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto 2 , Toronto, Ontario, Canada"},{"name":"Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital 3 , Toronto, Ontario, Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto 4 , Toronto, Ontario, Canada"},{"name":"ICES, Toronto 9 , Ontario, 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Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/48\/9\/1524\/833104\/dc242811.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/48\/9\/1524\/833104\/dc242811.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:33:51Z","timestamp":1781721231000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/48\/9\/1524\/160666\/Glucagon-Like-Peptide-1-Receptor-Agonists-and-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,6,26]]},"published-print":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dc24-2811","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}