{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:49:16Z","timestamp":1787496556462,"version":"build-2736575974"},"reference-count":34,"publisher":"American Diabetes Association","issue":"3","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"crossref","award":["MOHW107-TDU-B-211-123002"],"award-info":[{"award-number":["MOHW107-TDU-B-211-123002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"crossref","award":["MOHW108-TDU-B-211-133002"],"award-info":[{"award-number":["MOHW108-TDU-B-211-133002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"crossref","award":["MOHW110-TDU-B-211-124002"],"award-info":[{"award-number":["MOHW110-TDU-B-211-124002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"crossref","award":["MOHW111-TDU-B-211-134002"],"award-info":[{"award-number":["MOHW111-TDU-B-211-134002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Liver Disease Prevention and Treatment Research Foundation"},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2314-B-030-006-MY3"],"award-info":[{"award-number":["MOST 109-2314-B-030-006-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Newborns delivered by women with gestational diabetes mellitus (GDM) have accelerated intrauterine growth earlier than the current recommended screening period. We aimed to determine whether universal GDM screening using a single oral glucose intolerance test (OGTT) at 18\u201320 weeks\u2019 gestation improves pregnancy outcomes compared with standard screening at 24\u201328 weeks\u2019 gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>We conducted a dual-center, parallel, randomized controlled trial with a planned interim analysis in singleton pregnant women to compare the effect of midpregnancy screening for GDM at 18\u201320 weeks\u2019 gestation and standard screening at 24\u201328 weeks\u2019 gestation. GDM was universally screened and diagnosed using 75-g OGTTs and the International Association of the Diabetes and Pregnancy Study Groups criteria. The primary outcome was a composite measure of primary cesarean delivery, birth weight &amp;gt;90th percentile, neonatal hypoglycemia, cord serum C-peptide &amp;gt;90th percentile, gestational hypertension, preeclampsia, and birth trauma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The trial was stopped early for futility after the interim analysis. Of the 967 women included in the intention-to-treat analysis, the primary outcome was not significantly different between the two groups. Neonatal hypoglycemia was significantly lower and neonatal adiposity in women with GDM was higher in the midpregnancy screening group compared with the standard screening group. Adverse event rates were similar between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Advancing universal GDM screening to midpregnancy at 18\u201320 weeks\u2019 gestation may not improve pregnancy outcomes, except for a reduction in neonatal hypoglycemia. Newborns of women diagnosed with GDM through midpregnancy screening had higher neonatal adiposity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc25-0084","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T18:23:44Z","timestamp":1758651824000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Midpregnancy Screening for Gestational Diabetes Mellitus on Pregnancy Outcomes: The TESGO Randomized Controlled Trial"],"prefix":"10.2337","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-3567","authenticated-orcid":false,"given":"Chun-Heng","family":"Kuo","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University 1 , Taipei, Taiwan"},{"name":"School of Medicine, College of Medicine, Fu Jen Catholic University 2 , New Taipei City, 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