{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:26:30Z","timestamp":1782552390017,"version":"3.54.5"},"reference-count":20,"publisher":"American Diabetes Association","issue":"10","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["23K24792"],"award-info":[{"award-number":["23K24792"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP16K01823"],"award-info":[{"award-number":["JP16K01823"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP17K00924"],"award-info":[{"award-number":["JP17K00924"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"crossref","award":["965304"],"award-info":[{"award-number":["965304"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The predictive power of urinary titin for incident sarcopenia was studied in Japanese individuals with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>Baseline urinary titin levels were measured, and sarcopenia was evaluated annually using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Kaplan-Meier curves, Cox models, and time-dependent receiver operating characteristic analyses were used to assess incident sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 444 participants (median follow-up, 1,078 days), 41 developed sarcopenia. The high titin tertile was associated with an elevated sarcopenia risk (log-rank P = 0.04). Cox models associated titin with sarcopenia (adjusted hazard ratio per SD 1.37, 95% CI 1.05\u20131.77, P = 0.019) and low muscle strength. Risk estimates were consistent across subgroups, including those aged \u226570 years, men, individuals with BMI &amp;lt;25 kg\/m2, HbA1c \u22657%, and estimated glomerular filtration rate \u226560 mL\/min\/1.73 m2 (P for interaction &amp;gt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Elevated urinary titin levels predict sarcopenia and low muscle strength in individuals with type 2 diabetes, supporting its use as a noninvasive biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc25-1067","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T20:46:39Z","timestamp":1756154799000},"page":"1844-1849","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":5,"title":["Prediction of Sarcopenia Onset in Type 2 Diabetes Using Urinary Titin Levels: A Japanese Prospective Cohort Study"],"prefix":"10.2337","volume":"48","author":[{"given":"Hayato","family":"Tanabe","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine 1 , Fukushima, Japan"},{"name":"Department of Diabetes, Endocrinology, and Metabolism, and General Internal Medicine, Fukushima Medical University School of Medicine 2 , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine 1 , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University 3 , Tokushima, 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