{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:54:29Z","timestamp":1793080469000,"version":"4.5.0"},"reference-count":16,"publisher":"American Diabetes Association","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"name":"Vanderbilt Institute for Clinical and Translational","award":["VR762760"],"award-info":[{"award-number":["VR762760"]}]},{"DOI":"10.13039\/100007208","name":"Vanderbilt Ingram Cancer Center","doi-asserted-by":"crossref","award":["P30 CA68485"],"award-info":[{"award-number":["P30 CA68485"]}],"id":[{"id":"10.13039\/100007208","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020194","name":"Vanderbilt Digestive Disease Research Center","doi-asserted-by":"crossref","award":["DK058404"],"award-info":[{"award-number":["DK058404"]}],"id":[{"id":"10.13039\/100020194","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Breakthrough T1D","award":["3-PDF-2023-1320-A-N, 5-ECR-2020-950-A-N"],"award-info":[{"award-number":["3-PDF-2023-1320-A-N, 5-ECR-2020-950-A-N"]}]},{"name":"The JP Fletcher Foundation"},{"name":"Leona B and Harry M Helmsley Charitable Foundation"},{"name":"Division of Intramural Research, NIAID, NIH","award":["AI001175"],"award-info":[{"award-number":["AI001175"]}]},{"name":"NIH NIDDK","award":["5-ECR-2020-950-A-N"],"award-info":[{"award-number":["5-ECR-2020-950-A-N"]}]},{"name":"NIH NIDDK","award":["R01DK137997"],"award-info":[{"award-number":["R01DK137997"]}]},{"name":"NIH NIDDK","award":["R01DK139322"],"award-info":[{"award-number":["R01DK139322"]}]},{"name":"NIH NIDDK","award":["R03DK129979"],"award-info":[{"award-number":["R03DK129979"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, monogenic autoimmune disorder that may manifest as type 1 diabetes (T1D). Teplizumab, an anti-CD3 monoclonal antibody, delays progression of stage 2 T1D, but its effects in APS-1\u2013associated diabetes are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>We report clinical responses of two adolescents with APS-1 and stage 2 T1D who received 14-day courses of teplizumab. In one patient, pancreatic MRI and spectral immune cell phenotyping were performed before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Both patients exhibited improved glycemia. One who briefly required insulin recovered insulin independence 2 weeks after therapy. Pancreatic volume transiently increased, and circulating lymphocytes showed changes in homing receptors and senescence markers in the individual who underwent those studies. Nonpancreatic APS-1 manifestations were unchanged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Teplizumab may preserve \u03b2-cell function in APS-1\u2013associated T1D. Larger studies are needed to define efficacy, durability, and immunologic and tissue mechanisms in this rare context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc25-1444","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T18:18:03Z","timestamp":1762971483000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":5,"title":["Use of Teplizumab to Modulate Stage 2 Type 1 Diabetes in Two Individuals With Autoimmune Polyendocrine Syndrome 1"],"prefix":"10.2337","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7562-8420","authenticated-orcid":false,"given":"Christopher S.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ian Burr Division of Pediatric Endocrinology & Diabetes, Vanderbilt University Medical Center 1 , Nashville, 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