{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:20:42Z","timestamp":1791883242789,"version":"4.3.4"},"reference-count":56,"publisher":"American Diabetes Association","issue":"2","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Swedish Heart Lung Foundation","award":["2021-0273, 2023-0284"],"award-info":[{"award-number":["2021-0273, 2023-0284"]}]},{"name":"Region Stockholm","award":["RS2021-0933, FoUI-987255"],"award-info":[{"award-number":["RS2021-0933, FoUI-987255"]}]},{"name":"Konung Gustaf V:s och DrottningVictorias stiftelse."}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The association between diabetes and coronary stent failure is poorly established with second-generation drug-eluting stents (DES). We aimed to evaluate the risk of stent failure in patients with diabetes compared with those without diabetes after implantation of second-generation DES.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>All patients in Sweden who received second-generation DES between 2010 and 2020 were included and categorized into three groups: type 1 diabetes, type 2 diabetes, and without diabetes (reference group). The primary end point was stent failure, defined as in-stent restenosis or stent thrombosis. Adjusted hazard ratios (HRs) with 95% CIs were estimated by Cox regression models. Sensitivity analyses were performed to address missing data in covariates and account for death as a competing risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The study included 160,523 patients: 2,406 with type 1 diabetes, 43,377 with type 2 diabetes, and 114,740 without diabetes. Seventy-one percent were male. Over a mean follow-up of 4.5 years, 5,510 stent failure events occurred. The fully adjusted HR for stent failure was 2.28 (95% CI 1.97\u20132.65) for patients with type 1 and 1.35 (95% CI 1.27\u20131.44) for patients with type 2 diabetes, compared with individuals without diabetes. Sensitivity analyses confirmed the robustness of the findings, with both in-stent restenosis and stent thrombosis contributing to the increased risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>We observed a significantly higher risk of second-generation DES stent failure in individuals with type 1 diabetes followed by those with type 2 diabetes, compared with individuals without diabetes. This elevated risk was attributed to both in-stent restenosis and stent thrombosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc25-1624","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:02:10Z","timestamp":1764219730000},"page":"266-276","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":4,"title":["Coronary Stent Failure in Patients With Diabetes: A Nationwide Observational Study From SWEDEHEART"],"prefix":"10.2337","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5933-7295","authenticated-orcid":false,"given":"Irene","family":"Santos-Pardo","sequence":"first","affiliation":[{"name":"Unit of Cardiology, Department of Clinical Science and Education, Karolinska Institutet 1 , Stockholm, Sweden"},{"name":"Unit of Cardiovascular Interventions, Heart Institute and Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital 2 , 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