{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:53:00Z","timestamp":1792788780269,"version":"4.5.0"},"reference-count":39,"publisher":"American Diabetes Association","issue":"5","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"Socity Francophone de Diabaitologie"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>This nationwide study aimed to identify factors associated with 1-year mortality following a first diabetic foot ulcer (DFU) using the French National Health Data System (SNDS). A secondary objective was to analyze mortality after major lower-limb amputation within the same time frame.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A retrospective cohort analysis was conducted using SNDS data to identify adults with incident DFUs between January 2017 and December 2018, with 12 months of follow-up. Inclusion criteria combined hospitalization records and community care data. Cox proportional hazards models were used to estimate associations with mortality, adjusting for demographic, clinical, treatment, and care access variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 133,791 individuals with incident DFU, 14.6% died within 1 year, and 3.5% underwent a major amputation. Of those amputated, 28.8% died within a year. Independent predictors of 1-year mortality included male sex, older age, hospital-acquired DFU, insulin, major amputation, cardiovascular disease, cancer, dementia, ESKD, and liver disease. Protective factors included lipid-lowering therapy, glucagon-like peptide 1 (GLP-1) receptor agonists, and prior consultations with diabetologists, ophthalmologists, and podiatrists. Similar patterns were observed for postamputation mortality, with GLP-1 receptor agonists showing a consistent survival benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>One-year mortality after DFU remains high and is strongly linked to age and comorbidities. Community-based identification highlights the vulnerability of these patients, even outside hospital settings. Glucagon-like peptide 1 receptor agonists and structured, multidisciplinary follow-up are associated with better survival and should be prioritized. These findings underline the urgent need to reinforce preventive care and optimize care pathways for high-risk diabetic populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc25-2120","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:54:01Z","timestamp":1769784841000},"page":"730-739","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":7,"title":["GLP-1 Receptor Agonists Are Associated With Reduced Mortality Following Diabetic Foot Ulcers: A Nationwide Observational Study"],"prefix":"10.2337","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-8962","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Bonnet","sequence":"first","affiliation":[{"name":"Nutrition-Diabetes Department, University Hospital of Montpellier 1 , Montpellier, France"},{"name":"UMR 1302, Desbrest Institute of Epidemiology and Public Health, University of Montpellier 2 , INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Huguet","sequence":"additional","affiliation":[{"name":"Clinical Research and Epidemiology Unit, CHU Montpellier, University of Montpellier 3 , Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Avignon","sequence":"additional","affiliation":[{"name":"Nutrition-Diabetes Department, University Hospital of Montpellier 1 , Montpellier, France"},{"name":"UMR 1302, Desbrest Institute of Epidemiology and Public Health, University of Montpellier 2 , INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Duflos","sequence":"additional","affiliation":[{"name":"UMR 1302, Desbrest Institute of Epidemiology and Public Health, University of Montpellier 2 , INSERM, Montpellier, France"},{"name":"Clinical Research and Epidemiology Unit, CHU Montpellier, University of Montpellier 3 , Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-8222","authenticated-orcid":false,"given":"Ariane","family":"Sultan","sequence":"additional","affiliation":[{"name":"Nutrition-Diabetes Department, University Hospital of Montpellier 1 , Montpellier, France"},{"name":"PhyMedExp, INSERM U1046, CNRS UMR 9214, University of Montpellier 4 , Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"2026061812463495600_B1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N Engl J Med"},{"key":"2026061812463495600_B2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13047-020-00383-2","article-title":"Five year mortality and direct costs of care for 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