{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:08:30Z","timestamp":1790784510762,"version":"4.1.0"},"reference-count":36,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"name":"International Joint Research Center for Cardiovascular Precision Medicine of Shaanxi Province","award":["2020GHJD-14"],"award-info":[{"award-number":["2020GHJD-14"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070437, 82173538, 82473653"],"award-info":[{"award-number":["82070437, 82173538, 82473653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Shaanxi","award":["2023-ZDLSF-50"],"award-info":[{"award-number":["2023-ZDLSF-50"]}]},{"name":"Shandong Postdoctoral Science Foundation","award":["SDBX2023003"],"award-info":[{"award-number":["SDBX2023003"]}]},{"name":"Distinguished Professor of Changjiang Scholar Awards Program","award":["T2023116"],"award-info":[{"award-number":["T2023116"]}]},{"name":"Clinical Research Award of the First Affiliated Hospital of Xi\u2019an Jiaotong University","award":["XJTU1AF-CRF-2023-004, XJTU1AF-CRF-2024-003, XJTU1A"],"award-info":[{"award-number":["XJTU1AF-CRF-2023-004, XJTU1AF-CRF-2024-003, XJTU1A"]}],"id":[{"id":"https:\/\/ror.org\/02tbvhh96","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To examine the associations between cumulative BMI burden from childhood to adulthood and the risk of adult metabolic multimorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>This prospective cohort study used data from the Hanzhong Adolescent Hypertension Study (1987\u20132023). A total of 2,446 participants with at least two BMI measurements in both childhood (6\u201318 years) and adulthood (19\u201352 years) were included. Cumulative BMI exposure was quantified using total and incremental area under the curve (AUC). Outcomes included metabolic multimorbidity, defined as the presence of two or more or three or more metabolic diseases, specifically hypertension, diabetes, dyslipidemia, elevated liver enzymes\/bilirubin, and kidney damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher total and incremental BMI AUC during childhood, adulthood, and over the life course were consistently associated with an increased risk of adult metabolic multimorbidity (two or more diseases). For total AUC, odds ratios (ORs) ranged from 1.51 to 2.59 (all P &amp;lt; 0.05); for incremental AUC, ORs ranged from 1.94 to 4.33 (all P &amp;lt; 0.05). Compared with total AUC, incremental AUC showed a stronger association with metabolic multimorbidity in childhood (OR 4.33 [95% CI 2.93, 6.40] vs. 1.51 [1.17, 1.95], respectively). Conversely, total AUC exhibited a stronger association in adulthood than in childhood (OR 2.51 [2.08, 3.04] vs. 1.94 [1.62, 2.31]). Furthermore, the associations for adulthood and life course BMI AUC were significantly stronger in males than in females (P for interaction &amp;lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These findings highlight the importance of life stage\u2013specific strategies: curbing rapid BMI gain in childhood and maintaining long-term weight control throughout adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title\/>\n                  <\/jats:sec>","DOI":"10.2337\/dc25-2889","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:01:01Z","timestamp":1776866461000},"page":"1567-1575","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":1,"title":["Life Course Cumulative BMI Burden From Childhood to Adulthood and Risk of Metabolic Multimorbidity: A 36-Year Prospective Cohort Study"],"prefix":"10.2337","volume":"49","author":[{"given":"Tongshuai","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University 1 , Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Epidemiology, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University 2 , Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Epidemiology, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University 2 , Jinan, 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Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University 1 , Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University 1 , Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center 3 , Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University 1 , Xi'an, 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