{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:04:51Z","timestamp":1784574291606,"version":"3.55.0"},"reference-count":19,"publisher":"American Diabetes Association","issue":"8","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"funder":[{"DOI":"10.13039\/501100004756","name":"Emil Aaltosen SAAtiA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Juselius SAAtiA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen LAAketieteen SAAtiA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Funding for University-level Health Research"},{"DOI":"10.13039\/501100005744","name":"Lastentautien TutkimussAAtiA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Interest in screening for type 1 diabetes (T1D) is increasing, but studies assessing outcomes during the treatment period among individuals identified through population-based genetic screening and prospective follow-up remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>Characteristics at T1D diagnosis and 1-year treatment outcomes were compared between 126 at-risk children followed in the Type 1 Diabetes Prediction and Prevention (DIPP) study and 440 children diagnosed outside the screening program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>DIPP participants had significantly less frequent (P &amp;lt; 0.05) ketoacidosis (5.6% vs. 23.6%), dehydration, electrolyte imbalances, and need for intensive care, and shorter inpatient stays, than non-DIPP children. They showed lower median HbA1c levels (46 vs. 99 mmol\/mol [6.4 vs. 11.2%]) and insulin requirements (0.11 vs. 0.74 units\/kg\/day) both at diagnosis and 1 year later (55 vs. 61 mmol\/mol [7.2 vs. 7.7%]; 0.57 vs. 0.70 units\/kg\/day).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>DIPP participants had a milder clinical presentation at T1D diagnosis, with lower HbA1c levels and lower insulin requirements during the first year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc26-0136","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:24:02Z","timestamp":1781187842000},"page":"1474-1479","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Identification and Follow-up of At-Risk Children Mitigate Disease Severity and Improve Treatment Outcomes in Type 1 Diabetes"],"prefix":"10.2337","volume":"49","author":[{"given":"Oona","family":"K\u00e4hk\u00f6nen","sequence":"first","affiliation":[{"name":"Celiac Disease Research Center, Tampere University and Tampere University Hospital 1 , Tampere, Finland"},{"name":"Tampere Center for Child, Adolescent and Maternal Health Research and Centre for Child Health Research, Tampere University 2 , Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salla","family":"Kuusela","sequence":"additional","affiliation":[{"name":"Tampere Center for Child, Adolescent and Maternal Health Research and Centre for Child Health Research, Tampere University 2 , Tampere, Finland"},{"name":"Department of Pediatrics,Tampere University Hospital, Wellbeing Services County of Pirkanmaa 3 , Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-4651","authenticated-orcid":false,"given":"Jutta 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