{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T19:27:59Z","timestamp":1787254079327,"version":"build-2736575974"},"reference-count":44,"publisher":"American Diabetes Association","issue":"9","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.diabetesjournals.org\/journals\/pages\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To determine the real-world impact of initiating Omnipod 5 hybrid closed-loop (OP5-HCL) system on hypoglycemia frequency, duration, and awareness in people with type 1 diabetes and impaired awareness of hypoglycemia (IAH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A single-center study of people with type 1 diabetes and IAH (Gold score \u22654) with outcomes compared at baseline and 12 months after OP5-HCL initiation. The 28-day CGM data were analyzed to provide weekly sensor-detected hypoglycemia (SDH) data and glycemic metrics at baseline and 12 months. Outcomes of those with IAH were compared with age- and sex-matched control participants with normal awareness of hypoglycemia (NAH) (Gold score \u22642).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The study included 68 individuals (73.5% female; mean \u00b1 SD age 38.0 \u00b1 15.6 years; and diabetes duration 21.0 \u00b1 13.5 years). At baseline, people with IAH (n = 32) experienced both significantly higher time below range (TBR) (&amp;lt;3.9 mmol\/L) and more episodes of SDH compared with those with NAH (n = 32). The IAH group also experienced a significantly longer median duration of hypoglycemia episodes below 3.9 mmol\/L (SDH3.9) (33.5 vs. 24.5 min; P = 0.007). Initiation of OP5-HCL resulted in a decrease in TBR (from 2.8% to 1.7%; P = 0.024) and number of SDH3.9 episodes (from 5.4 to 4.0; P = 0.026). After 12 months of OP5-HCL use, the hypoglycemia burden experienced by those with IAH remained higher, including TBR (1.7% vs. 0.7%; P = 0.007) and number of SDH3.9 episodes (4.0 vs. 2.0; P = 0.013), but the difference in episode duration was no longer significant (29.8 vs. 28.0 min; P = 0.084).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Use of OP5-HCL by people with IAH reduced TBR and the number of episodes of SDH. However, the overall hypoglycemia burden remained significantly higher in those with IAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2337\/dc26-0422","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:28:08Z","timestamp":1783693688000},"page":"1627-1636","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["Effects of the Omnipod 5 Hybrid Closed-Loop System in People With Type 1 Diabetes With Impaired Awareness of Hypoglycemia"],"prefix":"10.2337","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2079-1071","authenticated-orcid":false,"given":"Iona R.","family":"Goodman","sequence":"first","affiliation":[{"name":"The Medical School, School of Medicine and Population Health, The University of Sheffield 1 , Sheffield, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Berry","sequence":"additional","affiliation":[{"name":"The Medical School, School of Medicine and Population Health, The University of Sheffield 1 , Sheffield, U.K."},{"name":"Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust 2 , Sheffield, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor H.","family":"McNally","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust 2 , Sheffield, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberte","family":"Martine-Edith","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, University of Leicester 3 , Leicester, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah J.C.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre, University of Leicester 3 , Leicester, 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