{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:32:54Z","timestamp":1740144774848,"version":"3.37.3"},"reference-count":20,"publisher":"American Diabetes Association","issue":"12","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DK085212"],"award-info":[{"award-number":["R01 DK085212"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Daniel B. Burke Endowed Chair for Diabetes Research"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.2337\/dci18-0034","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T20:25:31Z","timestamp":1542745531000},"page":"2441-2443","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":4,"title":["The Dynamic Origins of Type 1 Diabetes"],"prefix":"10.2337","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-1531","authenticated-orcid":false,"given":"R. David","family":"Leslie","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2025-5302","authenticated-orcid":false,"given":"Struan F.A.","family":"Grant","sequence":"additional","affiliation":[{"name":"Divisions of Human Genetics and Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA"},{"name":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"},{"name":"Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"2022031301210186000_B1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00125-015-3789-z","article-title":"Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment","volume":"59","author":"Leslie","year":"2016","journal-title":"Diabetologia"},{"key":"2022031301210186000_B2","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.2337\/dc18-0861","article-title":"Transcription factor 7-like 2 (TCF7L2) gene polymorphism and progression from single to multiple autoantibody positivity in individuals at risk for type 1 diabetes","volume":"41","author":"Redondo","year":"2018","journal-title":"Diabetes Care"},{"key":"2022031301210186000_B3","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1001\/jama.2013.6285","article-title":"Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children","volume":"309","author":"Ziegler","year":"2013","journal-title":"JAMA"},{"key":"2022031301210186000_B4","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1007\/s00125-017-4308-1","article-title":"Early prediction of autoimmune (type 1) diabetes","volume":"60","author":"Regnell","year":"2017","journal-title":"Diabetologia"},{"key":"2022031301210186000_B5","first-page":"661","article-title":"Genetic insights into common pathways and complex relationships among immune-mediated diseases","volume-title":"Nat Rev Genet","author":"Parkes","year":"2013"},{"key":"2022031301210186000_B6","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.2337\/db13-1777","article-title":"A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes","volume":"63","author":"Ferreira","year":"2014","journal-title":"Diabetes"},{"key":"2022031301210186000_B7","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2337\/dc17-0238","article-title":"Genetic and environmental interactions modify the risk of diabetes-related autoimmunity by 6 years of age: the TEDDY study","volume":"40","author":"Krischer","year":"2017","journal-title":"Diabetes Care"},{"key":"2022031301210186000_B8","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2337\/dc18-0087","article-title":"A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk","volume":"41","author":"Redondo","year":"2018","journal-title":"Diabetes Care"},{"key":"2022031301210186000_B9","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(13)62219-9","article-title":"The many faces of diabetes: a disease with increasing heterogeneity","volume":"383","author":"Tuomi","year":"2014","journal-title":"Lancet"},{"key":"2022031301210186000_B10","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.cell.2016.05.056","article-title":"Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans","volume":"165","author":"Vatanen","year":"2016","journal-title":"Cell"},{"key":"2022031301210186000_B11","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.2337\/db11-0364","article-title":"Genetic analysis of adult-onset autoimmune diabetes","volume":"60","author":"Howson","year":"2011","journal-title":"Diabetes"},{"key":"2022031301210186000_B12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2337\/db17-0802","article-title":"Plasma 25-hydroxyvitamin D concentration and risk of islet autoimmunity","volume":"67","author":"Norris","year":"2018","journal-title":"Diabetes"},{"key":"2022031301210186000_B13","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2337\/dc17-1983","article-title":"Early infant diet and islet autoimmunity in the TEDDY study","volume":"41","author":"Uusitalo","year":"2018","journal-title":"Diabetes Care"},{"key":"2022031301210186000_B14","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s00125-017-4365-5","article-title":"Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study","volume":"60","author":"L\u00f6nnrot","year":"2017","journal-title":"Diabetologia"},{"key":"2022031301210186000_B15","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1001\/jama.2016.2181","article-title":"Infections in early life and development of type 1 diabetes","volume":"315","author":"Beyerlein","year":"2016","journal-title":"JAMA"},{"key":"2022031301210186000_B16","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1210\/jc.2017-01490","article-title":"The role of age and excess body mass index in progression to type 1 diabetes in at-risk adults","volume":"102","author":"Ferrara","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031301210186000_B17","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2337\/dc12-0931","article-title":"Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7","volume":"36","author":"Hawa","year":"2013","journal-title":"Diabetes Care"},{"key":"2022031301210186000_B18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S2213-8587(17)30362-5","article-title":"Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank","volume":"6","author":"Thomas","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2022031301210186000_B19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S2213-8587(18)30051-2","article-title":"Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables","volume":"6","author":"Ahlqvist","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2022031301210186000_B20","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00125-018-4660-9","article-title":"Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk","volume":"61","author":"Tosur","year":"2018","journal-title":"Diabetologia"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/care.diabetesjournals.org\/syndication\/doi\/10.2337\/dci18-0034","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/41\/12\/2441\/527197\/dci180034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/41\/12\/2441\/527197\/dci180034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T05:07:21Z","timestamp":1647148041000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/41\/12\/2441\/36574\/The-Dynamic-Origins-of-Type-1-Diabetes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,11,12]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dci18-0034","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"type":"print","value":"0149-5992"},{"type":"electronic","value":"1935-5548"}],"subject":[],"published":{"date-parts":[[2018,11,12]]}}}