{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:11:33Z","timestamp":1773807093977,"version":"3.50.1"},"reference-count":29,"publisher":"American Diabetes Association","issue":"7","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/www.diabetesjournals.org\/content\/license"}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.2337\/dci19-0023","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:25:31Z","timestamp":1561076731000},"page":"1159-1161","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":14,"title":["The Cardiovascular Legacy of Good Glycemic Control: Clues About Mediators From the DCCT\/EDIC Study"],"prefix":"10.2337","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-3036","authenticated-orcid":false,"given":"Matthew C.","family":"Riddle","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes & Clinical Nutrition, Oregon Health & Science University, Portland, OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8072-2836","authenticated-orcid":false,"given":"Hertzel C.","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"2022031300204383600_B1","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1172\/JCI105886","article-title":"Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients","volume":"47","author":"Siperstein","year":"1968","journal-title":"J Clin Invest"},{"key":"2022031300204383600_B2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0002-9343(85)90583-2","article-title":"Value of glucose control in preventing complications of diabetes","volume":"79","author":"Kilo","year":"1985","journal-title":"Am J Med"},{"key":"2022031300204383600_B3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.7326\/0003-4819-124-1_Part_2-199601011-00002","article-title":"The pathophysiology of diabetic complications: how much does the glucose hypothesis explain?","volume":"124","author":"Nathan","year":"1996","journal-title":"Ann Intern Med"},{"key":"2022031300204383600_B4","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","author":"Nathan","year":"1993","journal-title":"N Engl J Med"},{"key":"2022031300204383600_B5","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","article-title":"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)","volume":"352","author":"UK Prospective Diabetes Study (UKPDS) Group","year":"1998","journal-title":"Lancet"},{"key":"2022031300204383600_B6","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0802743","article-title":"Effects of intensive glucose lowering in type 2 diabetes","volume":"358","author":"Gerstein","year":"2008","journal-title":"N Engl J Med"},{"key":"2022031300204383600_B7","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"Patel","year":"2008","journal-title":"N Engl J Med"},{"key":"2022031300204383600_B8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa0808431","article-title":"Glucose control and vascular complications in veterans with type 2 diabetes","volume":"360","author":"Duckworth","year":"2009","journal-title":"N Engl J Med"},{"key":"2022031300204383600_B9","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s00125-009-1470-0","article-title":"Intensive glucose control and macrovascular outcomes in type 2 diabetes","volume":"52","author":"Turnbull","year":"2009","journal-title":"Diabetologia"},{"key":"2022031300204383600_B10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.7326\/M17-0939","article-title":"Hemoglobin A1c targets for glycemic control with pharmacologic therapy for nonpregnant adults with type 2 diabetes mellitus: a guidance statement update from the American College of Physicians","volume":"168","author":"Qaseem","year":"2018","journal-title":"Ann Intern Med"},{"key":"2022031300204383600_B11","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1056\/NEJMoa052187","article-title":"Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes","volume":"353","author":"Nathan","year":"2005","journal-title":"N Engl J Med"},{"key":"2022031300204383600_B12","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2337\/dc15-1990","article-title":"Intensive diabetes treatment and cardiovascular outcomes in type 1 diabetes: the DCCT\/EDIC study 30-year follow-up","volume":"39","author":"The Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group.","year":"2016","journal-title":"Diabetes Care"},{"key":"2022031300204383600_B13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jama.2014.16107","article-title":"Association between 7 years of intensive treatment of type 1 diabetes and long-term mortality","volume":"313","author":"Orchard","year":"2015","journal-title":"JAMA"},{"key":"2022031300204383600_B14","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.2337\/dc15-2399","article-title":". Mortality in type 1 diabetes in the DCCT\/EDIC versus the general population","volume":"39","author":"The Diabetes Control and Complications Trial (DCCT)\/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group","year":"2016","journal-title":"Diabetes Care"},{"key":"2022031300204383600_B15","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2337\/dc18-1613","article-title":"Mediation of the effect of glycemia on the risk of CVD outcomes in type 1 diabetes: the DCCT\/EDIC study","volume":"42","author":"Bebu","year":"2019","journal-title":"Diabetes Care"},{"key":"2022031300204383600_B16","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.2337\/db15-1517","article-title":"Risk factors for cardiovascular disease in type 1 diabetes","volume":"65","author":"Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications (DCCT\/EDIC) Research Group","year":"2016","journal-title":"Diabetes"},{"key":"2022031300204383600_B17"},{"key":"2022031300204383600_B18","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1007\/s00125-017-4374-4","article-title":"The relationship of blood glucose with cardiovascular disease is mediated over time by traditional risk factors in type 1 diabetes: the DCCT\/EDIC study","volume":"60","author":"Bebu","year":"2017","journal-title":"Diabetologia"},{"key":"2022031300204383600_B19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijcard.2009.09.543","article-title":"The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors","volume":"141","author":"Thayer","year":"2010","journal-title":"Int J Cardiol"},{"key":"2022031300204383600_B20","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2337\/diacare.26.6.1895","article-title":"The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis","volume":"26","author":"Maser","year":"2003","journal-title":"Diabetes Care"},{"key":"2022031300204383600_B21","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.2337\/dc10-0125","article-title":"Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial","volume":"33","author":"Pop-Busui","year":"2010","journal-title":"Diabetes Care"},{"key":"2022031300204383600_B22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/01.HYP.0000111829.46090.92","article-title":"Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study","volume":"43","author":"Schram","year":"2004","journal-title":"Hypertension"},{"key":"2022031300204383600_B23","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.2337\/diabetes.54.11.3103","article-title":"Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications participants with type 1 diabetes","volume":"54","author":"Genuth","year":"2005","journal-title":"Diabetes"},{"key":"2022031300204383600_B24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00125-009-1308-9","article-title":"Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus","volume":"52","author":"Lutgers","year":"2009","journal-title":"Diabetologia"},{"key":"2022031300204383600_B25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2337\/diab.41.6.736","article-title":"Prospective study of microalbuminuria as predictor of mortality in NIDDM","volume":"41","author":"Mattock","year":"1992","journal-title":"Diabetes"},{"key":"2022031300204383600_B26","doi-asserted-by":"crossref","first-page":"980","DOI":"10.2337\/dc18-2483","article-title":"Dysglycemia and the density of the coronary vasa vasorum","volume":"42","author":"Gerstein","year":"2019","journal-title":"Diabetes Care"},{"key":"2022031300204383600_B27","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2337\/dc17-1144","article-title":"The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (The Diabetes & Aging Study)","volume":"42","author":"Laiteerapong","year":"2019","journal-title":"Diabetes Care"},{"key":"2022031300204383600_B28","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-year follow-up of intensive glucose control in type 2 diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"N Engl J Med"},{"key":"2022031300204383600_B29","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1414266","article-title":"Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetes","volume":"372","author":"Hayward","year":"2015","journal-title":"N Engl J Med"}],"container-title":["Diabetes Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/42\/7\/1159\/530143\/dci190023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/care\/article-pdf\/42\/7\/1159\/530143\/dci190023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T03:33:51Z","timestamp":1647142431000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/care\/article\/42\/7\/1159\/36170\/The-Cardiovascular-Legacy-of-Good-Glycemic-Control"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,6,12]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/dci19-0023","relation":{},"ISSN":["0149-5992","1935-5548"],"issn-type":[{"value":"0149-5992","type":"print"},{"value":"1935-5548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]}}}