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Follow-up of the cohort continues to add other aging-related outcomes and conditions to identify the long-term consequences of factors related to lifestyle and medical care. In this transition to a study of aging among individuals at risk for accelerated aging due to type 2 diabetes and overweight or obesity, the investigators have retrospectively reframed the study using the perspective of geroscience. This perspective strengthens the importance of lifestyle changes as a core component for medical care for these individuals to slow biological aging.<\/jats:p>","DOI":"10.2337\/dci25-0126","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:19:57Z","timestamp":1769181597000},"page":"1159-1162","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":0,"title":["The Look AHEAD Research Program: A 25-Year Retrospective From the Perspective of Geroscience"],"prefix":"10.2337","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-1949","authenticated-orcid":false,"given":"Mark A.","family":"Espeland","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wake Forest University School of Medicine 1 , Winston-Salem, NC"},{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine 2 , Winston-Salem, 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