{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:50:57Z","timestamp":1791453057456,"version":"4.3.3"},"reference-count":31,"publisher":"American Diabetes Association","issue":"Supplement_2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/www.diabetesjournals.org\/site\/license"}],"funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Develop","award":["K12-H0000850"],"award-info":[{"award-number":["K12-H0000850"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK32083"],"award-info":[{"award-number":["DK32083"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI50864"],"award-info":[{"award-number":["AI50864"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union, FP2 Programme NAIMT","award":["241447"],"award-info":[{"award-number":["241447"]}]}],"content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Autoimmune thyroiditis occurs in 10\u201325% of patients with type 1 diabetes (T1D). Most of these patients are also positive for thyroid peroxidase (TPO) antibodies. Thyroid dysfunction complicates T1D metabolic control and is a component of the autoimmune polyglandular syndrome (APS, type 2 or 3). Previous studies of isolated T1D and of T1D combined with other autoimmune disorders showed genetic susceptibility for alleles in HLA-DQB1 and -DRB1 and also CTLA4 and PTPN22.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESEARCH DESIGN AND METHODS<\/jats:title>\n                  <jats:p>We analyzed the Type 1 Diabetes Genetics Consortium Autoantibody Workshop data by differentiating those T1D probands with and without TPO antibodies or thyroid disease with respect to polymorphisms in HLA, CTLA4, INS, PTPN22, and VDR, taking into account the ethnic origin. Genotype and clinical\/immunogenic phenotype data were analyzed by gene counting methods and logistic regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The presence of TPO antibodies (25.2%) and thyroid disease (8.4%) was associated with older age, female sex, and presence of other autoantibodies (GAD65, ATPase, 21-OH) (all P &amp;lt; 0.001). The highest prevalence was in patients of Hispanic ancestry (31%) and the lowest in those of African ancestry (8%). In T1D non-Hispanic whites, HLA-DRB1*0101 is significantly (P &amp;lt; 0.0001) less frequent in TPO-positive than in TPO-negative individuals, whereas HLA-DRB1*0404, -DQB1*0301, and -DPB1*0201 are significantly (P &amp;lt; 0.0001) more frequent. Subjects with a high titer of TPO autoantibodies and with thyroid disease were associated with female sex and older age and negatively associated with DRB1*0401-DQB1*0302 (P &amp;lt; 0.0001). No significant differences were observed for an association of TPO positivity or thyroid disease with single nucleotide polymorphisms in the INS, CTLA4, or VDR loci, with nominal significance (P = 0.01) for PTPN22 R620W variant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Thyroid autoimmunity is highly prevalent in T1D patients of non-Hispanic white, Asian, or Hispanic origin. The strongest disease risk is conferred by female sex and older age. This risk is modulated by HLA-DRB1 and HLA-DPB1 loci. The immunogenetic profile for T1D with thyroid autoimmunity may identify distinct pathways regulating polyglandular autoimmunity and disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/dcs15-2005","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T19:17:54Z","timestamp":1443122274000},"page":"S21-S28","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":19,"title":["Genetics of Autoimmune Thyroiditis in Type 1 Diabetes Reveals a Novel Association With <i>DPB1*<\/i>0201: Data From the Type 1 Diabetes Genetics Consortium"],"prefix":"10.2337","volume":"38","author":[{"given":"Heinrich","family":"Kahles","sequence":"first","affiliation":[{"name":"University Hospital Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela R.","family":"Fain","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood 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diabetes genetics consortium families","volume":"57","author":"Erlich","year":"2008","journal-title":"Diabetes"},{"key":"2022031218590215400_B11","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.2337\/db14-1730","article-title":"Type 1 Diabetes Genetics Consortium. Novel association between immune-mediated susceptibility loci and persistent autoantibody positivity in type 1 diabetes","volume":"64","author":"Brorsson","year":"2015","journal-title":"Diabetes"},{"key":"2022031218590215400_B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jaut.1997.0170","article-title":"Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus","volume":"11","author":"Pietropaolo","year":"1998","journal-title":"J Autoimmun"},{"key":"2022031218590215400_B13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1086\/429096","article-title":"Analysis of families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes","volume":"76","author":"Criswell","year":"2005","journal-title":"Am J Hum 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(Oxf)"},{"key":"2022031218590215400_B17","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ng1885","article-title":"A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC","volume":"38","author":"de Bakker","year":"2006","journal-title":"Nat Genet"},{"key":"2022031218590215400_B18","doi-asserted-by":"crossref","first-page":"D913","DOI":"10.1093\/nar\/gkq1128","article-title":"Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations","volume":"39","author":"Gonzalez-Galarza","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2022031218590215400_B19","doi-asserted-by":"crossref","first-page":"D1171","DOI":"10.1093\/nar\/gkq998","article-title":"The IMGT\/HLA database","volume":"39","author":"Robinson","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2022031218590215400_B20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/08916939409014664","article-title":"HLA-DPB1 polymorphisms in patients with hyperthyroid Graves\u2019 disease and early onset myasthenia gravis","volume":"17","author":"Ratanachaiyavong","year":"1994","journal-title":"Autoimmunity"},{"key":"2022031218590215400_B21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2362.1994.tb01090.x","article-title":"HLA-DPB1 polymorphisms on the MHC-extended haplotypes of families of patients with Graves\u2019 disease: two distinct HLA-DR17 haplotypes","volume":"24","author":"Ratanachaiyavong","year":"1994","journal-title":"Eur J Clin Invest"},{"key":"2022031218590215400_B22","doi-asserted-by":"crossref","first-page":"e16635","DOI":"10.1371\/journal.pone.0016635","article-title":"Comprehensive genotyping in two homogeneous Graves\u2019 disease samples reveals major and novel HLA association 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