{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:23:56Z","timestamp":1773285836224,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,1,1]]},"abstract":"<jats:p>A thirty-six-year-old female brittle diabetic presented in a confused state complaining of intense thirst. She had a twelve-year history of known diabetes mellitus but for the previous five years had been well controlled. Four years before admission she was found to be euthyroid with a PBI of 6.8 meg. per 100 ml.<\/jats:p>\n               <jats:p>On examination she was dehydrated and without Kussmaul respirations. Blood sugar on admission was 1,590 mg.\/100 ml. and only a trace of acetone was detected in urine. Calculated serum osmolality was 365 milliosmols\/liter. The patient responded well to 800 U. of Regular Insulin and eight liters of intravenous hypotonie solutions. However the pulse rate remained at 140\/min. with no evidence of heart failure or infection; EKG showed sinus tachycardia. Evaluation of the patient's thyroid function revealed hyperthyroidism. I-131 uptake after twenty-four hours was 74 per cent. The glucocorticosteroids were found to be within normal limits.<\/jats:p>\n               <jats:p>Four months after receiving methimazole 40 mg.\/day the hyperthyroidism and diabetes mellitus were well controlled.<\/jats:p>","DOI":"10.2337\/diab.19.1.70","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T05:37:01Z","timestamp":1418276221000},"page":"70-71","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":4,"title":["Hyperglycemia and Hyperosmolarity in a Brittle Diabetic with Thyrotoxicosis"],"prefix":"10.2337","volume":"19","author":[{"given":"R","family":"Jacobson","sequence":"first","affiliation":[{"name":"Department of Mediane, Sinai Hospital of Baltimore, Inc.\u2008Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Horenstein","sequence":"additional","affiliation":[{"name":"Department of Mediane, Sinai Hospital of Baltimore, Inc.\u2008Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Kassel","sequence":"additional","affiliation":[{"name":"Department of Mediane, Sinai Hospital of Baltimore, Inc.\u2008Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/19\/1\/70\/345191\/19-1-70.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/19\/1\/70\/345191\/19-1-70.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:16:18Z","timestamp":1667405778000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/19\/1\/70\/3480\/Hyperglycemia-and-Hyperosmolarity-in-a-Brittle"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.19.1.70","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,1,1]]}}}