{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:28:21Z","timestamp":1759541301381},"reference-count":0,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Studies of immunoreactive insulin (IRI) and human growth hormone (HGH) secretion were undertaken in a subject with chronic hypoglycemia associated with hepatoma. Fasting IRI concentrations were below 3 \u03bcU.\/ml. at glucose concentrations of 30 mg.\/100 ml. IRI secretion was not stimulated by acutely administered glucose, tolbutamide, glucagon or arginine. IRI concentrations rose after tolbutamide when plasma glucose was raised to 100 mg.\/100 ml. by sustained glucose infusion. Fasting ILA (muscle, adipose) levels were not elevated.<\/jats:p>\n                  <jats:p>Fasting HGH concentrations were below 5 m\u03bcg.\/ml.; secretion was stimulated by arginine despite hypoglycemia. During glucose administration, HGH concentrations rose to 45 m\u03bcg.\/ml. as FFA levels fell from 2,250 to 233 \u03bcEq.\/L. Estimated total glucose utilization rate was high (7.5 mg.\/kg.\/hr. at a plasma glucose concentration of 100 mg.\/100 ml.).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>(1) Glucose, or some metabolic product is required for human insulin secretion; (2) HGH secretion after arginine is not inhibited at low glucose concentrations; (3) FFA may exert an inhibitory role in HGH regulation; (4) Hypoglycemia in our subject with hepatoma was associated with increased glucose utilization, not with hyper-insulinism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2337\/diab.20.9.607","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T05:38:33Z","timestamp":1418276313000},"page":"607-614","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":8,"title":["Studies of Insulin and Growth Hormone Secretion in a Subject with Hepatoma and Hypoglycemia"],"prefix":"10.2337","volume":"20","author":[{"given":"John A","family":"Colwell","sequence":"first","affiliation":[{"name":"Medical Service, Veterans Administration Research Hospital, Department of Medicine and Section of Endocrinology and Metabolism, Northwestern University Medical School\u2008Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F","family":"Wilber","sequence":"additional","affiliation":[{"name":"Medical Service, Veterans Administration Research Hospital, Department of Medicine and Section of Endocrinology and Metabolism, Northwestern University Medical School\u2008Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/20\/9\/607\/336019\/20-9-607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/20\/9\/607\/336019\/20-9-607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:20:02Z","timestamp":1667406002000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/20\/9\/607\/3584\/Studies-of-Insulin-and-Growth-Hormone-Secretion-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1971,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.20.9.607","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,9,1]]}}}