{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:52:06Z","timestamp":1759938726102},"reference-count":0,"publisher":"American Diabetes Association","issue":"11","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1975,11,1]]},"abstract":"<jats:p>Alloxan-diabetic rats with fasting blood glucose levels above 300 mg.\/100 ml. were treated with intrajejunal administration of water-in-oil-in-water (W\/O\/W) insulin emulsions via an indwelling catheter at a dose of either 25 or 50 U.\/100 gm. body weight, three times daily for five to fourteen days. The course of diabetes was followed by determinations of glucose levels in blood and urine.<\/jats:p>\n               <jats:p>During treatment a significant reduction in urinary glucose levels was observed in all rats studied. In two rats treated with 25 U.\/100 gm., fasting blood glucose levels did not change significantly. In four of five rats treated with 50 U.\/100 gm., W\/O\/W insulin emulsions significantly lessened hyperglycemia during treatment. Quantitative estimates suggested that the effectiveness of 50 U.\/100 gm. of intrajejunal W\/O\/W insulin emulsions was comparable to that after intramuscular regular insulin at doses between 1 and 2 U.\/100 gm.<\/jats:p>\n               <jats:p>These results would indicate that diabetes can be controlled by enteral administration of insulin preparations.<\/jats:p>","DOI":"10.2337\/diab.24.11.971","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:13:09Z","timestamp":1379610789000},"page":"971-976","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":14,"title":["Short-Term Treatment of Alloxan-Diabetic Rats with Intrajejunal Administration of Water-in-Oil-in-Water Insulin Emulsions"],"prefix":"10.2337","volume":"24","author":[{"given":"Motoaki","family":"Shichiri","sequence":"first","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Kawamori","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Yoshida","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Etani","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Hoshi","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Izumi","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Shigeta","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Osaka","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Osaka University Medical School\u2008Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/24\/11\/971\/347935\/24-11-971.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/24\/11\/971\/347935\/24-11-971.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:24:51Z","timestamp":1667406291000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/24\/11\/971\/4615\/Short-Term-Treatment-of-Alloxan-Diabetic-Rats-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1975,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.24.11.971","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,11,1]]}}}