{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:30:22Z","timestamp":1762079422813},"reference-count":0,"publisher":"American Diabetes Association","issue":"11","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,11,1]]},"abstract":"<jats:p>This study was designed to determine if hyperglucagonemia approximating that believed to be present in the portal vein of poorly controlled diabetics can exert metabollcally deleterious effects in insulin-treated diabetics. Three juvenile-type diabetics and one maturity-onset-type patient were given glucagon intravenously at a dose of 6 ng.\/kg.\/min. for 24 hours while receiving a continuous infusion of Insulin. This raised their plasma IRG levels from an average of 122 \u00b1 15 pg.\/ml. on the control day to 594 \u00b1 60 pg.\/ml. Mean plasma glucose concentration, measured at two-hour intervals around the clock, averaged 200 \u00b1 20 mg.\/dl. on the control day and increased significantly in all four patients to 293 \u00b1 18 mg.\/dl. (p &amp;lt; 0.05) during glucagon administration; fasting glucose rose from 138 \u00b1 10 mg.\/dl. to 201 \u00b1 17 (p &amp;lt; 0.05). Glucose excretion rose significantly from the control value of 36 \u00b1 14 gm. per 24 hours to 152 \u00b1 19 gm. per 24 hours (p &amp;lt; 0.05). The excretion of both urea nitrogen and ketones also increased significantly (p &amp;lt; 0.05) during glucagon administration. The three juvenile-diabetic patients also received a glucagon infusion at a rate of only 3 ng.\/kg.\/min., and in each evidence of deterioration in metabolic control was observed. In every experiment, termination of the glucagon infusion was followed by a recession in the metabolic abnormalities.<\/jats:p>\n               <jats:p>These data indicate that exogenous hyperglucagonemia of the magnitude believed to be present in the portai vein of uncontrolled diabetics can cause metabolic deterioration in diabetics receiving continuous insulin treatment.<\/jats:p>","DOI":"10.2337\/diab.26.11.1034","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:13:09Z","timestamp":1379610789000},"page":"1034-1039","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":23,"title":["Effects of Exogenous Hyperglucagonemia in Insulin-treated Diabetics"],"prefix":"10.2337","volume":"26","author":[{"given":"Philip","family":"Raskin","sequence":"first","affiliation":[{"name":"Veterans Administration Hospital\u2008Dallas, Texas\u2008the University of Texas Southwestern Medical School, Department of Internal Medicine\u2008Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger H","family":"Unger","sequence":"additional","affiliation":[{"name":"Veterans Administration Hospital\u2008Dallas, Texas\u2008the University of Texas Southwestern Medical School, Department of Internal Medicine\u2008Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/26\/11\/1034\/643653\/26-11-1034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/26\/11\/1034\/643653\/26-11-1034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:27:43Z","timestamp":1667406463000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/26\/11\/1034\/4331\/Effects-of-Exogenous-Hyperglucagonemia-in-Insulin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1977,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.26.11.1034","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,11,1]]}}}