{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:48:16Z","timestamp":1771627696588,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,3,1]]},"abstract":"<jats:p>Insulin can modulate glucagon-stimulated hepatic glucose production and is considered to be the major factor acting in vivo to exert a counterregulatory action to glucagon. The insulindependent diabetic, therefore, might be especially vulnerable to enhanced hepatic glucose production promoted by glucagon. To investigate this hypothesis, low-dose glucagon infusions were administered to normal and diabetic men to compare the effects of glucagon on net splanchnic glucose production (NSGP). Four normal and three insulin-dependent, ketosis-prone, hyperglycemic diabetic men (insulin withheld for 24 hours) underwent brachialartery-hepatic-vein catheterization. Each received a 90-minute glucagon infusion at 5 ng.\/kg.\/min. Glucagon levels rose four-tofivefold in both groups, plateauing at 300\u2013600 pg.\/ml. In the normals, NSGP rose from 92 \u00b1 12 to 211 \u00b1 31 mg.\/min. at 15 minutes and returned to basal levels by 45 minutes. Insulin measured in the hepatic vein rose from 19 \u00b1 6 to 33 \u00b1 11 \/\u03bcU.\/ml., while plasma glucose rose 17 mg.\/dl. In the insulin-dependent diabetics, NSGP rose from 78 \u00b1 24 to a peak of 221 \u00b1 33 mg.\/min. at 30 minutes and then fell sharply to 113 \u00b1 15 mg.\/min. at 60 minutes despite continuing hyperglucagonemia. Plasma glucose in the diabetics rose 21 mg.\/dl.<\/jats:p>\n               <jats:p>These data suggest a mechanism that acts to rapidly diminish glucagon-induced hepatic glucose production in diabetic man but does not appear to be mediated by increased insulin secretion.<\/jats:p>","DOI":"10.2337\/diab.26.3.177","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:13:09Z","timestamp":1379610789000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":61,"title":["Transient Stimulatory Effect of Sustained Hyperglucagonemia on Splanchnic Glucose Production in Normal and Diabetic Man"],"prefix":"10.2337","volume":"26","author":[{"suffix":"Jr","given":"J D","family":"Bomboy","sequence":"first","affiliation":[{"name":"Veterans Administration Hospital and Department of Medicine, Vanderbilt University School of Medicine\u2008Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S B","family":"Lewis","sequence":"additional","affiliation":[{"name":"Veterans Administration Hospital and Department of Medicine, Vanderbilt University School of Medicine\u2008Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W W","family":"Lacy","sequence":"additional","affiliation":[{"name":"Veterans Administration Hospital and Department of Medicine, Vanderbilt University School of Medicine\u2008Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B C","family":"Sinclair-Smith","sequence":"additional","affiliation":[{"name":"Veterans Administration Hospital and Department of Medicine, Vanderbilt University School of Medicine\u2008Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Liljenquist","sequence":"additional","affiliation":[{"name":"Veterans Administration Hospital and Department of Medicine, Vanderbilt University School of Medicine\u2008Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/26\/3\/177\/349212\/26-3-177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/26\/3\/177\/349212\/26-3-177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:28:03Z","timestamp":1667406483000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/26\/3\/177\/4540\/Transient-Stimulatory-Effect-of-Sustained"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,3,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.26.3.177","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,3,1]]}}}