{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:15:49Z","timestamp":1761513349924},"reference-count":0,"publisher":"American Diabetes Association","issue":"11","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,11,1]]},"abstract":"<jats:p>There is an increased prevalence (P &amp;lt; 0.001) of IgA deficiency in children with juvenile-onset insulin-dependent diabetes mellitus (9\/366) but not in adults with insulin-dependent diabetes (0\/421). The juvenile diabetics with IgA deficiency have other immune-associated diseases, such as thyroiditis and chronic active hepatitis, and have a history of infections. Four of the nine IgA-deficient diabetics we studied have autoantibodies to endocrine organs. Seven of eight have the HLA-B8, a proportion significantly (P &amp;lt; 0.05) greater than control populations. Based on the clinical findings of IgA deficiency and multiple autoantibodies in patients with ataxia-telangiectasia and chronic mucocutaneous candidiasis, diseases associated with thymus deficiency, we suspect that thymus deficiency and autoimmunity may play a role in the pathogenesis of some types of juvenile-onset diabetes mellitus. In addition, an excess morbidity of the IgA-deficient juvenile diabetic population may explain the lack of IgA deficiency in older insulin-dependent diabetic individuals.<\/jats:p>","DOI":"10.2337\/diab.27.11.1092","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:13:09Z","timestamp":1379610789000},"page":"1092-1097","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":27,"title":["Immunopathology of Juvenile-onset Diabetes Mellitus: I. IgA Deficiency and Juvenile Diabetes"],"prefix":"10.2337","volume":"27","author":[{"suffix":"Jr","given":"William I","family":"Smith","sequence":"first","affiliation":[{"name":"Departments of Pathology, Medicine, and Pediatrics, University of Pittsburgh School of Medicine\u2008Pittsburgh, Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce S","family":"Rabin","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medicine, and Pediatrics, University of Pittsburgh School of Medicine\u2008Pittsburgh, Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Huellmantel","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medicine, and Pediatrics, University of Pittsburgh School of Medicine\u2008Pittsburgh, Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H Van","family":"Thiel","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medicine, and Pediatrics, University of Pittsburgh School of Medicine\u2008Pittsburgh, Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Drash","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Medicine, and Pediatrics, University of Pittsburgh School of Medicine\u2008Pittsburgh, Pennsylvania 15261"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/27\/11\/1092\/349751\/27-11-1092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/27\/11\/1092\/349751\/27-11-1092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:29:19Z","timestamp":1667406559000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/27\/11\/1092\/5192\/Immunopathology-of-Juvenile-onset-Diabetes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1978,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.27.11.1092","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,11,1]]}}}