{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:26:56Z","timestamp":1787635616075,"version":"build-2736575974"},"reference-count":0,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,6,1]]},"abstract":"<jats:p>C-peptide secretion was studied in eight juvenile diabetics during the remission phase of the disease. The release of C-peptide was measured after a (1) normal intravenous glucose tolerance test, (2) a double glucose tolerance test, (3) an arginine infusion, and (4) after an intravenous glucose tolerance test followed by an arginine infusion. Under all conditions the intravenous glucose load had only a minimal effect on the secretion of C-peptide, while arginine alone or after the intravenous glucose tolerance test stimulated the release of the peptide in all patients. Pretreatment with glucose did not augment the effect of arginine on C-peptide release.<\/jats:p>\n               <jats:p>The results indicate that during the remission phase of juvenileonset diabetes the endocrine pancreas does not recognize glucose as an appropriate signal for C-peptide release and cannot transform the amplifying effect of glucose into a higher hormonal secretion rate.<\/jats:p>","DOI":"10.2337\/diab.27.6.670","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:13:09Z","timestamp":1379610789000},"page":"670-676","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":18,"title":["C-Peptide Secretion During the Remission Phase of Juvenile Diabetes"],"prefix":"10.2337","volume":"27","author":[{"given":"E","family":"Heinze","sequence":"first","affiliation":[{"name":"Center of Internal Medicine and Pediatrics, University of Ulm\/Donau\u2008Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Beischer","sequence":"additional","affiliation":[{"name":"Center of Internal Medicine and Pediatrics, University of Ulm\/Donau\u2008Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Keller","sequence":"additional","affiliation":[{"name":"Center of Internal Medicine and Pediatrics, University of Ulm\/Donau\u2008Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Winkler","sequence":"additional","affiliation":[{"name":"Center of Internal Medicine and Pediatrics, University of Ulm\/Donau\u2008Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Teller","sequence":"additional","affiliation":[{"name":"Center of Internal Medicine and Pediatrics, University of Ulm\/Donau\u2008Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E F","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Center of Internal Medicine and Pediatrics, University of Ulm\/Donau\u2008Federal Republic of Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/27\/6\/670\/349755\/27-6-670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/27\/6\/670\/349755\/27-6-670.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:29:59Z","timestamp":1667406599000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/27\/6\/670\/4462\/C-Peptide-Secretion-During-the-Remission-Phase-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.27.6.670","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6,1]]}}}