{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:20:09Z","timestamp":1756992009709},"reference-count":0,"publisher":"American Diabetes Association","issue":"11","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,11,1]]},"abstract":"<jats:p>Ten patients with unstable insulin-dependent diabetes mellitus, mean duration 17.5 yr, all treated with highly purified porcine NPH insulin twice daily, were placed on highly purified porcine regular insulin subcutaneously four times daily for 2 days. Thereafter a preplanned intravenous insulin infusion was given for 54 h. Insulin in an amount corresponding to 24-h insulin requirement was infused by a portable infusion pump. Immediately before the main meals the prandial infusion program was released by the patients by pushing a button. Capillary blood glucose was taken every 30 min during the day and every 2 h during the night. Endogenous insulin secretion was calculated by measuring the C-peptide response after 1 mg of glucagon intravenously. Insulin antibodies were measured in all patients.<\/jats:p>\n               <jats:p>Insulin antibody concentration was low in most cases, and only one patient reacted to glucagon by a significant but low rise of C-peptide. After an equilibration period of 5 h, mean blood glucose (MBG) was in the physiologic range in 6 of 10 patients during the infusion period. MGB in the 10 diabetics averaged 5.5 \u00b11.0 mmol\/L (mean \u00b1 SD) compared with 4.4 \u00b1 0.4 mmol\/L in nondiabetic controls. The mean amplitude of glycemic excursions (MAGE) was 4.1 \u00b11.4 mmol\/L (mean \u00b1 SD) against 1.8 \u00b1 0.6 mmol\/L in control subjects. MBG, MAGE, and glucosuria were significantly reduced on the infusion days compared with the days on subcutaneous insulin.<\/jats:p>\n               <jats:p>It is concluded that near-normal blood glucose fluctuations can be obtained in unstable diabetics by a preplanned prandial insulin infusion program activated by diabetic patients themselves.<\/jats:p>","DOI":"10.2337\/diab.28.11.974","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:13:09Z","timestamp":1379610789000},"page":"974-979","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":9,"title":["Patient-controlled Portable Insulin Infusion Pump in Diabetics"],"prefix":"10.2337","volume":"28","author":[{"given":"J\u00f8rgen","family":"Bojsen","sequence":"first","affiliation":[{"name":"Finsen Laboratory and the Steno Memorial Hospital\u2008Gentofte, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Deckert","sequence":"additional","affiliation":[{"name":"Finsen Laboratory and the Steno Memorial Hospital\u2008Gentofte, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"K\u00f8lendorf","sequence":"additional","affiliation":[{"name":"Finsen Laboratory and the Steno Memorial Hospital\u2008Gentofte, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birthe","family":"L\u00f8rup","sequence":"additional","affiliation":[{"name":"Finsen Laboratory and the Steno Memorial Hospital\u2008Gentofte, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/28\/11\/974\/350300\/28-11-974.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/28\/11\/974\/350300\/28-11-974.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:31:06Z","timestamp":1667406666000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/28\/11\/974\/5899\/Patient-controlled-Portable-Insulin-Infusion-Pump"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1979,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.28.11.974","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,11,1]]}}}