{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:37:52Z","timestamp":1779237472544,"version":"3.51.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,1,1]]},"abstract":"<jats:p>The effect of sodium DL-lactate administration on insulin release in anesthetized dogs has been studied. Eleven mongrel dogs were infused with sodium DL-lactate for 20 min at the rate of 20 mg\/kg \u00b7 min. Lactate infusion produced simultaneous increases in blood glucose and plasma insulin levels in the pancreatico-duodenal vein. To determine whether lactate stimulated insulin secretion directly, sodium DL-lactate was rapidly injected into the pancreatic artery of six dogs; this pulse induced a significant increase in insulin release from pancreatic B-cells, even in the absence of a measurable change in blood glucose. Diazoxide, when infused in six dogs, blocked lactate-induced insulin secretion. These findings indicate that lactate, as do other circulating energy fuels, may play a role in the physiologic control of insulin secretion.<\/jats:p>","DOI":"10.2337\/diab.29.1.33","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"33-36","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Sodium DL-Lactate on Insulin Secretion in Anesthetized Dogs"],"prefix":"10.2337","volume":"29","author":[{"given":"G","family":"Federspil","sequence":"first","affiliation":[{"name":"Institute of Semeiotic Medicine and Surgical Clinic, University of Padua\u2008Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zaccaria","sequence":"additional","affiliation":[{"name":"Institute of Semeiotic Medicine and Surgical Clinic, University of Padua\u2008Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pedrazzoli","sequence":"additional","affiliation":[{"name":"Institute of Semeiotic Medicine and Surgical Clinic, University of Padua\u2008Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Zago","sequence":"additional","affiliation":[{"name":"Institute of Semeiotic Medicine and Surgical Clinic, University of Padua\u2008Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"DePalo","sequence":"additional","affiliation":[{"name":"Institute of Semeiotic Medicine and Surgical Clinic, University of Padua\u2008Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Scandellari","sequence":"additional","affiliation":[{"name":"Institute of Semeiotic Medicine and Surgical Clinic, University of Padua\u2008Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/29\/1\/33\/350375\/29-1-33.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/29\/1\/33\/350375\/29-1-33.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:32:34Z","timestamp":1667406754000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/29\/1\/33\/4601\/Effects-of-Sodium-DL-Lactate-on-Insulin-Secretion"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.29.1.33","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1,1]]}}}