{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:05:07Z","timestamp":1774973107369,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,1,1]]},"abstract":"<jats:p>Rats made diabetic with streptozotocin received a single subcutaneous implant of an insulin polymer pellet that released insulin continuously at approximately 2 U\/day. Continuous normoglycemia was achieved for up to 1 mo. Mean glucose level for treated animals was 113 mg\/dl as compared with 398 mg\/dl for untreated diabetic controls. Diurnal blood glucose values for treated animals ranged from 71 to 116 mg\/dl. Polyuria and glycosuria were corrected by the presence of the insulin + polymer. Treated animals gained weight normally and reached a mean weight of 350 g, whereas untreated control animals lost weight, to a mean of 150 g. When insulin + polymer preparations were periodically implanted and removed at 7-day intervals, normoglycemia was only associated with the presence of implants.<\/jats:p>","DOI":"10.2337\/diab.29.1.37","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"37-40","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":67,"title":["One Month of Sustained Release of Insulin from a Polymer Implant"],"prefix":"10.2337","volume":"29","author":[{"given":"Halimena M","family":"Creque","sequence":"first","affiliation":[{"name":"Department of Surgery, Children's Hospital Medical Center and Harvard Medical School\u2008Boston, Massachusetts\u2008Department of Nutrition and Food Science, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Children's Hospital Medical Center and Harvard Medical School\u2008Boston, Massachusetts\u2008Department of Nutrition and Food Science, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judah","family":"Folkman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Children's Hospital Medical Center and Harvard Medical School\u2008Boston, Massachusetts\u2008Department of Nutrition and Food Science, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/29\/1\/37\/350427\/29-1-37.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/29\/1\/37\/350427\/29-1-37.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:32:34Z","timestamp":1667406754000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/29\/1\/37\/4600\/One-Month-of-Sustained-Release-of-Insulin-from-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.29.1.37","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1,1]]}}}