{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:37:41Z","timestamp":1788489461037,"version":"build-2803163510"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:p>Streptozotocin (SZ) was given to 2-day-old neonatal rats, and, during their subsequent development, the interrelationships between plasma glucose, plasma insulin, pancreatic islet morphology, and hormone content were examined.<\/jats:p>\n               <jats:p>At 4 days of age, a peak of hyperglycemia was observed (SZ, 349 \u00b1 8 mg\/dl versus control (C), 127 \u00b1 2) that was associated with a marked reduction of B-cell numbers (SZ, 26.5 \u00b1 2.6% B-cell per islet versus C, 72.8 \u00b1 0.8%). By 10 days of age the SZ animals became normoglycemic with partial recovery of the B-cell number (SZ, 39.6 \u00b1 2.1% versus C, 64.0 \u00b1 2.6%). By 6 weeks hyperglycemia returned (SZ, 345 \u00b1 5.2 mg\/dl versus C, 171 \u00b1 6.2) with B-cell number of the SZ being 72% of the C (SZ, 48.8 \u00b1 2.4% versus C, 67.5 \u00b1 1.5%). This hyperglycemia and reduced B-cell number persisted to at least 13 wk age. Despite a marked reduction of pancreatic insulin content observed during development, there was little effect upon glucagon or somatostatin content.<\/jats:p>\n               <jats:p>At 6 wk of age, the plasma insulin concentration was only 30% of C, which suggests an insulin secretory defect beyond that which could be accounted for by the modest B-cell reduction. The present study indicates that even though active regeneration of B-celle occurred after early injury, the capacity for ultimate normalization was limited. The resultant moderate reduction in B-cell number may be associated with a functional defect in glucose-stimulated insulin secretion.<\/jats:p>","DOI":"10.2337\/diab.30.1.64","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":165,"title":["Responses of Neonatal Rat Islets to Streptozotocin: Limited B-Cell Regeneration and Hyperglycemia"],"prefix":"10.2337","volume":"30","author":[{"given":"S","family":"Bonner-Weir","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Medical College of Virginia\u2008Richmond, Virginia 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D F","family":"Trent","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Medical College of Virginia\u2008Richmond, Virginia 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Honey","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Medical College of Virginia\u2008Richmond, Virginia 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G C","family":"Weir","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Medical College of Virginia\u2008Richmond, Virginia 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/30\/1\/64\/351254\/30-1-64.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/30\/1\/64\/351254\/30-1-64.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:35:35Z","timestamp":1667406935000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/30\/1\/64\/4998\/Responses-of-Neonatal-Rat-Islets-to-Streptozotocin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.30.1.64","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1,1]]}}}